Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading
| Autor: | Guizhi Zhu, Xiaoyuan Chen, Richen Li, Justin A. Smolen, Fuwu Zhang, Lu Su, Shiyi Zhang, Ashlee A. Jahnke, Karen L. Wooley, Sarosh Khan, Mahmoud Elsabahy |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Paclitaxel chemistry General Materials Science sense organs Nanocarriers 0210 nano-technology |
| Zdroj: | Nanoscale. 9:15773-15777 |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/c7nr05935c |
| Popis: | Multifunctional polyphosphoester-based nanoparticles capable of loading paclitaxel (PTX) both chemically and physically were prepared, achieving an ultrahigh equivalent PTX aqueous concentration of 25.30 mg mL-1. The dual-loaded nanoparticles were effective in killing cancer cells, which has the potential to minimize the amount of nanocarriers needed for clinical applications, due to their ultrahigh loading capacity. |
| Databáze: | OpenAIRE |
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