Mining copper transport genes
| Autor: | Nancy C. Andrews |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
X Chromosome
Copper metabolism Iron Recombinant Fusion Proteins chemistry.chemical_element Metallochaperones Mice Copper Transport Proteins Animals Humans Gene Cation Transport Proteins Copper Transporter 1 Adenosine Triphosphatases Multidisciplinary biology Neuropeptides Membrane Proteins Biological Transport Copper Transport protein Biochemistry chemistry Copper-Transporting ATPases Chaperone (protein) Copper-transporting ATPases biology.protein Commentary Dietary Copper Carrier Proteins Molecular Chaperones |
| Popis: | Copper is not only a ubiquitous metal in our modern, technological environment, it is also essential for the function of most living organisms. Just as it allows for the movement of electrons through wires, it helps catalyze the movement of electrons within biological molecules. Making up only 0.01% of the Earth's crust, it is relatively scarce in the environment and must be actively scavenged. Until recently, little was known about how trace amounts of dietary copper are assimilated by intestinal absorptive cells to enter the body. In this issue of PNAS, three groups report genetic studies that may give insight into this process. Kuo et al. (1) and Lee et al. (2) report targeted gene disruption of a putative copper uptake molecule, Ctr1. In an accompanying report, Hamza and colleagues (3) report disruption of the gene encoding a copper chaperone, which escorts copper to sites of use and export within the cell. |
| Databáze: | OpenAIRE |
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