MicroRNAs in Metabolism and Metabolic Disorders
| Autor: | Veerle Rottiers, Anders M. Näär |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_treatment
Endocrine System Biology Carbohydrate metabolism Article Metabolic Diseases Non-alcoholic Fatty Liver Disease microRNA medicine Glucose homeostasis Homeostasis Humans Insulin Obesity Molecular Biology Transcription factor Genetics Metabolic Syndrome Sterol Regulatory Element Binding Proteins Lipid metabolism Cell Biology Lipid Metabolism Sterol regulatory element-binding protein Cell biology Fatty Liver MicroRNAs Cholesterol Glucose Signal transduction Oligoribonucleotides Antisense Signal Transduction |
| Popis: | MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors. Other metabolic miRNAs, such as miR-103 and miR-107, regulate insulin and glucose homeostasis, whereas miRNAs such as miR-34a are emerging as key regulators of hepatic lipid homeostasis. The discovery of circulating miRNAs has highlighted their potential as both endocrine signalling molecules and disease markers. Dysregulation of miRNAs may contribute to metabolic abnormalities, suggesting that miRNAs may potentially serve as therapeutic targets for ameliorating cardiometabolic disorders. |
| Databáze: | OpenAIRE |
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