Evaluation of the clinical efficacy of subconjunctival injection of clindamycin in the treatment of naturally occurring infectious bovine keratoconjunctivitis

Autor: Cengiz Cetin, Ebru Ozel, Mutlu Temizel, Sezgin Şentürk
Přispěvatelé: Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı., Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Bölümü., Şentürk, Sezgin, Çetin, Cengiz, Temizel, Mutlu, Özel, Ebru, AAH-5069-2021
Rok vydání: 2007
Předmět:
Veterinary sciences
Injection
Photophobia
Mornxella bovis
Moraxella bovis
Keratoconjunctivitis
Oxytetracycline
Gastroenterology
Severity of Illness Index
Controlled clinical trial
Pathology
Medicine
Bos
Antiinfective agent
biology
Clindamycin
Moraxella-bovis
Mycobacterium bovis
Anti-Bacterial Agents
Clinical trial
Hospitalization
Treatment Outcome
Pyoderma
Randomized controlled trial
Anesthesia
Florfenicol
Hydrochloride
medicine.symptom
Conjunctiva
medicine.drug
Chemosis
Keratoconjunctivitis
Infectious
medicine.medical_specialty
Subconjunctival injection
Blepharospasm
Cattle Diseases
IBK
Corneal ulceration
Bovinae
Article
Injections
Dogs
Internal medicine
Animalia
Animals
General Veterinary
business.industry
Moraxella Bovoculi
Moraxella (Moraxella) Bovis
Animal
Animal disease
medicine.disease
biology.organism_classification
Infectious bovine keratoconjunctivitis
Isolation and purification
Cattle disease
Cattle
business
Controlled study
Tuberculosis
Bovine
Zdroj: Veterinary ophthalmology. 10(3)
ISSN: 1463-5216
Popis: Objective To determine the clinical efficacy of subconjunctival injection of clindamycin in the treatment of naturally occurring infectious bovine keratoconjunctivitis (IBK). Animals studied Clinically, out of 81 animals examined, 46 were found to be suffering from IBK of variable severity. The ocular secretions were collected and cultured for Moraxella bovis. The study included 36 Holstein cattle from which M. Bovis was isolated. These animals ranged between 4 and 28 months of age. Procedures The severity of the clinical findings were scored as normal, mild, moderate, and severe. Clindamycin was injected subconjunctivally at a total dose of 150 mg (1 mL), once daily for 3 days to the test group (n = 18); isotonic saline solution (1 mL) was administered to the control group. After treatment, all cattle were re-examined and clinical response was evaluated on days 3, 7 and 15 post-treatment. Results Compared with the control group and prior to treatment, all active lesions such as blepharospasm, epiphora, photophobia, chemosis, corneal edema, and corneal ulceration were generally resolved by day 15 after subconjunctival injection of clindamycin. Severity of IBK lesions increased on days 3 and 7, compared to baseline in the control group administered isotonic saline solution. Conclusions The results of this study suggest that subconjunctival injection of clindamycin is effective in the treatment of naturally occurring infectious bovine keratoconjunctivitis.
Databáze: OpenAIRE
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