The immune response to tuberculosis infection in the setting of Helicobacter pylori and helminth infections
| Autor: | Sharon Perry, Alicia H. Chang, Shufang Yang, Luz Sanchez, T. D. Haggerty, Julie Parsonnet |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Tuberculosis Adolescent Epidemiology Helminthiasis Article Helicobacter Infections Interferon-gamma Young Adult Immune system Latent Tuberculosis medicine Helminths Humans Young adult Tuberculosis Pulmonary Interleukin-13 biology Latent tuberculosis Helicobacter pylori Coinfection Middle Aged medicine.disease biology.organism_classification bacterial infections and mycoses Infectious Diseases Cross-Sectional Studies Immunology Interleukin-2 Female Interleukin-5 |
| Zdroj: | Epidemiology and infection. 141(6) |
| ISSN: | 1469-4409 |
| Popis: | SUMMARYWe screened 176 healthy, adult (aged 18–55 years) US refugees from tuberculosis (TB)-endemic countries to evaluate whether cytokine responses to latent TB infection (LTBI) are modified in the setting of concurrentH. pyloriand helminth infection. As measured by the Quantiferon-TB GOLD interferon-γ release assay, a total 38 (22%) subjects had LTBI, of which 28 (74%) also wereH. pyloriseropositive and/or helminth infected. Relative to ten subjects with LTBI only, 16 subjects with concurrentH. pyloriinfection had significantly elevated levels of IFN-γ, and nine subjects with bothH. pyloriand helminth infection had significantly elevated levels of IFN-γ, IL-2, IL-13, and IL-5.H. pyloriis associated with enhanced IFN-γ responses to TB, even in the setting of concurrent helminth infection. Efficacy of TB vaccines may vary with the co-existence of these three infections in the developing world. |
| Databáze: | OpenAIRE |
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