Effects of silk solution against laminectomy-induced dural adhesion formation and inflammation in a rat model
| Autor: | Keun Wook Lee, Soo Young Choi, Won Sik Eum, Ki-Yeon Yoo, Chi Hern Lee, Min Jea Shin, Kyu Hyung Han, Yong-Jun Cho, Dae Won Kim, Jinseu Park, Hyo Sang Jo |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty medicine.medical_treatment Interleukin-1beta Rat model Silk Inflammation Nitric Oxide 03 medical and health sciences 0302 clinical medicine medicine Animals business.industry fungi Laminectomy General Medicine Adhesion Spinal surgery Rats Disease Models Animal 030104 developmental biology SILK medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurosurgery: Spine. 29:599-607 |
| ISSN: | 1547-5654 |
| DOI: | 10.3171/2018.4.spine171164 |
| Popis: | OBJECTIVEAdhesion formation is one of the most common complications following laminectomy. The efficiency of antiadhesive agents is required to prevent postsurgical adhesion. Therefore, the authors investigated the effects of silk solution against laminectomy-induced dural adhesion formation in a rat model.METHODSThe authors prepared the silk solution from silkworms. Laminectomies were performed between L3 and L5 in all rats. MediShield was used as a control. The effects of silk solution against laminectomy-induced dural adhesion formation and inflammation were confirmed by histological examination and Western blot analysis.RESULTSLaminectomy-induced dural adhesion formation was drastically reduced in silk solution–treated rats (Grade 2) compared to vehicle-treated rats (Grade 3). Dural adhesion formation was significantly reduced in rats that received treatment with silk solution or MediShield, which is a known antiadhesion drug. In addition, combined treatment with silk solution and MediShield showed greater reductions in inflammation compared to the silk solution– or MediShield-treated rats (p > 0.05).CONCLUSIONSIn this study, the authors demonstrated that silk solution effectively reduced postlaminectomy dural adhesion formation in rats. Although further studies on the long-term effects are necessary to validate these results, silk solution may potentially serve as an antiadhesion agent in neurological procedures. |
| Databáze: | OpenAIRE |
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