A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination
| Autor: | H. Maloni, L. R. Tranquill, Rhonda R. Voskuhl, Dale E. McFarlin, Gladys E. Deibler, Henry F. McFarland, Roger D. Stone |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Gene isoform Multiple Sclerosis T-Lymphocytes T cell Molecular Sequence Data Immunology Clinical Neurology Immunodominance Biology Autoantigens Article Epitope Cell Line Epitopes Myelin Exon T lymphocyte medicine Humans Immunology and Allergy Amino Acid Sequence Remyelination Aged Brain Myelin Basic Protein Exons Middle Aged Magnetic Resonance Imaging Molecular biology Pedigree Myelin basic protein Alternative Splicing medicine.anatomical_structure Genes Neurology biology.protein Female Neurology (clinical) T-Lymphocytes Cytotoxic |
| Zdroj: | Journal of Neuroimmunology |
| ISSN: | 0165-5728 |
| Popis: | Although the major isoform of myelin basic protein (MBP) in the healthy adult CNS is the 18.5-kDa protein, other isoforms containing exon 2 encoded protein (21.5 kDa and 20.2 kDa) exist and are expressed primarily during myelin formation. Since remyelination is a prominent feature in MS lesions, we examined the frequencies of T cell lines (TCLs) specific for epitopes within exon 2 encoded MBP (X2MBP), and also within 18.5-kDa MBP, in members of a multiplex family with MS. TCLs specific for X2MBP were as prevalent as TCLs specific for immunodominant epitopes within 18.5-kDa MBP. In addition, while frequencies of TCLs specific for 18.5-kDa MBP were no different between the affected and unaffected, the frequency of X2MBP-specific TCLs correlated with disease. |
| Databáze: | OpenAIRE |
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