Gingival crevicular fluid biomarkers in type 1 diabetes mellitus: A case–control study
Autor: | Catherine Giannopoulou, Alkisti Zekeridou, Margaux Roy, Maria Sereti, Giacomo Gastaldi |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Adult
Male medicine.medical_specialty Wilcoxon signed-rank test Periodontal examination type 1 diabetes Population periodontal disease AGEs Crevicular fluid Gingivitis Internal medicine medicine Humans education General Dentistry Glycated Hemoglobin Inflammation ddc:616 education.field_of_study Type 1 diabetes business.industry Interleukin-8 IL‐8 MMP‐8 Case-control study Original Articles medicine.disease ddc:617.6 lcsh:RK1-715 Diabetes Mellitus Type 1 Matrix Metalloproteinase 8 gingival crevicular fluid Case-Control Studies lcsh:Dentistry Cohort Female Original Article medicine.symptom business Biomarkers |
Zdroj: | Clinical and Experimental Dental Research, Vol 7, Iss 2, Pp 170-178 (2021) Clinical and Experimental Dental Research (2020) Clinical and Experimental Dental Research |
ISSN: | 2057-4347 |
Popis: | Objective The aim of the study is to compare the levels of Gingival Crevicular Fluid (GCF) interleukin 8 (IL‐8), matrix metalloproteinase 8 (MMP‐8) and advanced glycated‐end products (AGEs) in a cohort of type 1 diabetic (T1D) subjects and healthy controls. Material and methods GCF samples and periodontal examination were assessed in 50 subjects with T1D (30 males and 20 females; mean age: 35.2 years) recruited from the Diabetology Unit of the Geneva University Hospitals and in 50 control subjects matched for gender, age and smoking status. Samples were assessed for IL‐8 and MMP‐8 using a bead array multianalyte detection system and for AGEs the ELISA. The two groups were compared using the Wilcoxon signed rank test. Results The mean HbA1c differed significantly between the groups (8.3% for the T1D group vs. 5.2% for the control group, p 8%), again no significant differences could be identified for any of the biochemical markers. Conclusions T1D subjects, particularly the younger ones, exhibited more inflammation compared to the matched healthy controls. Results on the GCF expression of IL‐8, MMP‐8 and AGEs did not differ between the groups. The diabetic population of our cohort was for the most part fairly‐controlled, with little if any complications and with presence of only mild type of periodontal disease, as 68% had gingivitis. |
Databáze: | OpenAIRE |
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