Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets The Result of Drug Substance Incorporation

Autor: Encarna García-Montoya, Ewelina Baran, Władysław P. Węglarz, Jolanta Klaja, A. Birczyński, Piotr Kulinowski, Przemysław Dorożyński, Dorota Majda, Ewelina Juszczyk
Rok vydání: 2021
Předmět:
Technology
Polymers
Endothermic process
Article
hydrophilic matrix tablets
sodium alginate
Síntesi de fàrmacs
swelling
chemistry.chemical_compound
Drug synthesis
Differential scanning calorimetry
medicine
magnetic resonance imaging
General Materials Science
Lamellar structure
Sodium salicylate
chemistry.chemical_classification
Microscopy
QC120-168.85
Nanopartícules
QH201-278.5
mass transport
Polymer
Engineering (General). Civil engineering (General)
polymer dissolution
TK1-9971
Polímers
Drug delivery systems
polymer hydration
Sistemes d'alliberament de medicaments
Descriptive and experimental mechanics
Chemical engineering
chemistry
X-ray microtomography
drug solubility
sustained release drug delivery
Nanoparticles
Electrical engineering. Electronics. Nuclear engineering
TA1-2040
Swelling
medicine.symptom
Salicylic acid
Karl Fischer titration
Zdroj: Dipòsit Digital de la UB
Universidad de Barcelona
Materials
Volume 14
Issue 21
Materials, Vol 14, Iss 6531, p 6531 (2021)
Popis: The purpose was to show, using destructive/nondestructive methods, that the interplay between water, tablet structure, and composition determine the unique spatiotemporal hydration pattern of polymer-based matrices. The tablets containing a 1:1 w/w mixture of sodium alginate with salicylic acid (ALG/SA) or sodium salicylate (ALG/SNA) were studied using Karl Fischer titration, differential scanning calorimetry, X-ray microtomography, and magnetic resonance imaging. As the principal results, matrix specific features were detected, e.g., “locking” of the internal part of the matrix (ALG/SA)
existence of lamellar region associated with detection of free/freezing water (ALG/SA)
existence of water penetrating the matrix forming specific region preceding infiltration layer (ALG/SNA)
switch in the onset temperature of endothermic water peak associated with an increase in the fraction of non-freezing water weight per dry matrix weight in the infiltration layer (ALG/SNA). The existence of complicated spatiotemporal hydration patterns influenced by matrix composition and molecular properties of constituents has been demonstrated.
Databáze: OpenAIRE
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