Antimicrobial and cytotoxic activity of green synthesis silver nanoparticles targeting skin and soft tissue infectious agents

Autor: Florencia Dinorah Rojas, Javier Mussin, Eduardo San Martín-Martínez, Gustavo Giusiano, Viviana Robles-Botero, Rocio Guadalupe Casañas-Pimentel, Letizia Angiolella
Rok vydání: 2021
Předmět:
0301 basic medicine
Silver
Science
030106 microbiology
TRADITIONAL MEDICINE
Nanoparticle
Metal Nanoparticles
Microbial Sensitivity Tests
Asteraceae
Silver nanoparticle
Antioxidants
Article
Microbiology
03 medical and health sciences
chemistry.chemical_compound
Immune system
Antibiotic resistance
Anti-Infective Agents
Phenols
NANOPARTICLES
Humans
ANTIMICROBIAL
purl.org/becyt/ford/3.4 [https]
Skin Diseases
Infectious
Cytotoxicity
Flavonoids
Multidisciplinary
Acanthospermum australe
biology
Plant Extracts
Soft Tissue Infections
Fungi
Green Chemistry Technology
biology.organism_classification
Antimicrobial
Skin diseases
Silver nitrate
030104 developmental biology
chemistry
Leukocytes
Mononuclear
Medicine
Nanoparticles
SKIN INFECTIONS
purl.org/becyt/ford/3 [https]
nanotecnology
antimicrobic
medicinal plant
Zdroj: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
ISSN: 2045-2322
Popis: Combining traditional medicine with nanotechnology therefore opens the door to innovative strategies for treating skin and soft tissue infections (SSTIs) and also contributes to the fight against the rise of antimicrobial resistance. Acanthospermum australe (Loefl.) Kuntze is a medicinal plant used by indigenous peoples in northeastern Argentina to treat SSTIs. Spherical and stable silver nanoparticles (AgNPs) of 14 ± 2 nm were synthesized from the aqueous extract of A. australe and silver nitrate. The antimicrobial activity against main species causing SSTIs and cytotoxicity on peripheral blood mononuclear cells of AgNP solution and its synthesis components were evaluated. Compared to its synthesis components, AgNP solution showed greater antimicrobial activity and lower cytotoxicity. The antimicrobial activity of AgNPs was due to the silver and not to the metabolites of the aqueous extract present on the surface of the nanoparticles. The plant extract played an important role in the formation of stable AgNPs and acted as a modulator of cytotoxic and immune responses. Fil: Mussin, Javier Esteban. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina Fil: Robles Botero, Viviana. Consejo Nacional de Ciencia y Tecnología; México Fil: Casañas-Pimentel, Rocío. Consejo Nacional de Ciencia y Tecnología; México Fil: Rojas, Florencia. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina Fil: Angiolella, Letizia. Università degli Studi di Roma "La Sapienza"; Italia Fil: San Martín Martínez, Eduardo. Consejo Nacional de Ciencia y Tecnología; México Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Databáze: OpenAIRE
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