Frequency and characteristics of familial melanoma in Spain: the FAM-GEM-1 Study
| Autor: | Miguel-Ángel Idoate-Gastearena, José Pedro Vaqué, Javier Valdivia, Jordi Rubió-Casadevall, Miguel Angel Berciano Guerrero, Nuria Blázquez Sánchez, Luis De la Cruz-Merino, JM Caminal, Elísabeth Pérez Ruiz, Javier Martin-Broto, PEDRO REDONDO, Jose Luis González Larriba, Ana Arance, CARMEN GUILLEN PONCE, Rosa M Marti, Jose Luis Rodriguez-Peralto, Francisco Aya, Eduardo Nagore, Clara Olier-Garate, Salvador Martín Algarra, Delvys Rodriguez-Abreu, Ivan Marquez-Rodas, Virginia Palomar Coloma, Aram Boada, Jose Luis Perez-Gracia, Alfonso Martín Carnicero |
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| Přispěvatelé: | Spanish Multidisciplinary Group of Melanoma (GEM)., [Márquez-Rodas,I] Servicio de Oncología Médica, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. [Martín González,M] Servicio de Dermatología, Hospital Ramón y Cajal, Madrid, Spain. [Nagore,E] Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain. [Gómez-Fernández,C, Maseda,R] Servicio de Dermatología, Hospital La Paz, Madrid, Spain. [Avilés-Izquierdo,JA] Servicio de Dermatología, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. [Maldonado-Seral,C] Servicio de Dermatología, Hospital Universitario Central de Asturias, Oviedo, Spain. [Soriano,V] Servicio de Oncología Médica, Instituto Valenciano de Oncología, Valencia, Spain. [Majem-Tarruella,M] Servicio de Oncología Médica, Hospital de Sant Pau, Barcelona, Spain. [Maseda,R]Servicio de Oncología Médica, Hospital de San Pedro, Logroño, Spain. [Puertolas,T] Servicio de Oncología, Hospital Universitario Miguel Servet, Zaragoza, Spain. [Godoy,E] Servicio de Dermatología, Hospital de Cabueñes, Gijon, Spain. [Cerezuela,P] Servicio de Oncología Médica, Hospital General Universitario Santa Lucia, Cartagena, Spain. [Ochoa de Olza,M] Servicio de Oncología Médica, Instituto Catalan de Oncología, Hospitalet, Spain. [Campos,B] Servicio de Oncología Médica, Hospital Lucus Augusti, Lugo, Spain. [Pérez-Ruiz,E] Servicio de Oncología Médica, Hospital Costa del Sol, Marbella, Spain. [Soria,A] Servicio de Oncología Médica, Hospital Ramón y Cajal, Madrid, Spain. [Gil-Arnaiz,I] Servicio de Oncología Medica, Hospital Reina Sofía, Tudela, Spain. [Gonzalez-Cao,M] Servico de Oncología Médica, Instituto Dexeus, Barcelona, Spain. [Galvez,E] Servicio de Oncología Médica, Hospital de Elda, Alicante, Spain. [Arance,A] Servicio de Oncología Medica, Hospital Clinic, Barcelona, Spain. [Belon,J] Servicio de Oncología Médica, Clínica Oncogranada, Granada, Spain. [Cruz-Merino,L de la] Servicio de Oncología Médica, Hospital Virgen de la Macarena, Sevilla, Spain. [Martín-Algarra,S] Departamento de Oncología, Clínica Universidad de Navarra, Pamplona, Spain., Universitat de Barcelona |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Oncology Pathology Skin Neoplasms Multivariate analysis lcsh:Medicine Disease Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings] Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Named Groups::Persons::Population Groups::Ethnic Groups::Hispanic Americans [Medical Subject Headings] Risk Factors Family history lcsh:Science Melanoma Pancreas cancer Factores de Riesgo Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings] Univariate analysis Multidisciplinary Incidence Incidence (epidemiology) Pronóstico Dermatología Middle Aged Multiple melanoma Familial melanoma Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Division::Cell Nucleus Division::Mitosis [Medical Subject Headings] Female Research Article medicine.medical_specialty Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance::Multivariate Analysis [Medical Subject Headings] The FAM-GEM-1 Mitosis Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors::Melanoma [Medical Subject Headings] Internal medicine Pancreatic cancer Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Photosensitivity Disorders::Sunburn [Medical Subject Headings] medicine Humans Genetic Predisposition to Disease Espanya Risk factor Quemadura Solar neoplasms Càncer de pàncrees Amilial melanoma patients business.industry lcsh:R Disciplines and Occupations::Health Occupations::Medicine::Dermatology [Medical Subject Headings] medicine.disease Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Pancreatic Neoplasms [Medical Subject Headings] Spain Multivariate Analysis Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings] lcsh:Q business Neoplasias Pancreáticas |
| Zdroj: | PLoS ONE, Vol 10, Iss 4, p e0124239 (2015) PLoS ONE Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Dadun. Depósito Académico Digital de la Universidad de Navarra instname PLoS One r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Recercat. Dipósit de la Recerca de Catalunya Dipòsit Digital de la UB Universidad de Barcelona |
| ISSN: | 1932-6203 |
| Popis: | Introduction Familial history of melanoma is a well-known risk factor for the disease, and 7% melanoma patients were reported to have a family history of melanoma. Data relating to the frequency and clinical and pathological characteristics of both familial and non-familial melanoma in Spain have been published, but these only include patients from specific areas of Spain and do not represent the data for the whole of Spain. Patients and methods An observational study conducted by the Spanish Group of Melanoma (GEM) analyzed the family history of patients diagnosed with melanoma between 2011 and 2013 in the dermatology and oncology departments. Results In all, 1047 patients were analyzed, and 69 (6.6%) fulfilled criteria for classical familial melanoma (two or more first-degree relatives diagnosed with melanoma). Taking into account other risk factors for familial melanoma, such as multiple melanoma, pancreatic cancer in the family or second-degree relatives with melanoma, the number of patients fulfilling the criteria increased to 165 (15.8%). Using a univariate analysis, we determined that a Breslow index of less than 1 mm, negative mitosis, multiple melanoma, and a history of sunburns in childhood were more frequent in familial melanoma patients, but a multivariate analysis revealed no differences in any pathological or clinical factor between the two groups. Conclusions Similar to that observed in other countries, familial melanoma accounts for 6.6% of melanoma diagnoses in Spain. Although no differences in the multivariate analysis were found, some better prognosis factors, such as Breslow index, seem more frequent in familial melanoma, which reflect a better early detection marker and/or a different biological behavior. |
| Databáze: | OpenAIRE |
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