Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure
| Autor: | Thomas S. Rector, Spencer H. Kubo, Kathleen Mullen, Kamalesh M Pillai, Ronald T. Sih, Linda K. Tschumperlin, Alan J. Bank |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Physical Exertion Placebo-controlled study Cardiac Output Low Administration Oral Vasodilation Placebo Arginine Nitric oxide chemistry.chemical_compound Forearm Double-Blind Method Physiology (medical) Medicine Humans Cross-Over Studies omega-N-Methylarginine business.industry Blood flow Middle Aged medicine.disease Crossover study Surgery medicine.anatomical_structure chemistry Regional Blood Flow Vasoconstriction Anesthesia Heart failure Quality of Life Female Nitric Oxide Synthase Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 93(12) |
| ISSN: | 0009-7322 |
| Popis: | Background Patients with heart failure have reduced peripheral blood flow at rest, during exercise, and in response to endothelium-dependent vasodilators. Nitric oxide formed from l -arginine metabolism in endothelial cells contributes to regulation of blood flow under these conditions. A randomized, double-blind crossover study design was used to determine whether supplemental oral l -arginine can augment peripheral blood flow and improve functional status in patients with moderate to severe heart failure. Methods and Results Fifteen subjects were given 6 weeks of oral l -arginine hydrochloride (5.6 to 12.6 g/d) and 6 weeks of matched placebo capsules in random sequence. Compared with placebo, supplemental oral l -arginine significantly increased forearm blood flow during forearm exercise, on average from 5.1±2.8 to 6.6±3.4 mL·min −1 ·dL −1 ( P l -arginine compared with placebo, as indicated by increased distances during a 6-minute walk test (390±91 versus 422±86 m, P P l -arginine also improved arterial compliance from 1.99±0.38 to 2.36±0.30 mL/mm Hg ( P P Conclusions Supplemental oral l -arginine had beneficial effects in patients with heart failure. Further studies are needed to confirm the therapeutic potential of supplemental oral l -arginine and to identify mechanisms of action in patients with heart failure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|