Interchangeability of meningococcal group C conjugate vaccines with different carrier proteins in the United Kingdom infant immunisation schedule
| Autor: | Helen Findlow, Nick Andrews, Elizabeth Miller, Anna England, David Goldblatt, Pauline Waight, Xilian Bai, Bassam Hallis, Ray Borrow, Polly Burbidge, Shamez N Ladhani, Mary Matheson, Emma Pearce |
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| Rok vydání: | 2015 |
| Předmět: |
Blood Bactericidal Activity
Pediatrics medicine.medical_specialty Meningococcal Vaccines Meningococcal vaccine medicine Humans Diphtheria toxin General Veterinary General Immunology and Microbiology biology Tetanus business.industry Diphtheria Public Health Environmental and Occupational Health Toxoid Infant food and beverages medicine.disease Antibodies Bacterial United Kingdom Vaccination Treatment Outcome Infectious Diseases biology.protein Molecular Medicine Antibody Carrier Proteins business Glycoconjugates Blood sampling |
| Zdroj: | Vaccine. 33:648-655 |
| ISSN: | 0264-410X |
| Popis: | An open, non-randomised study was undertaken in England during 2011-12 to evaluate vaccine antibody responses in infants after completion of the routine primary infant immunisation schedule, which included two doses of meningococcal group C (MenC) conjugate (MCC) vaccine at 3 and 4 months. Any of the three licensed MCC vaccines could be used for either dose, depending on local availability. Healthy term infants registered at participating general practices (GPs) in Hertfordshire and Gloucestershire, UK, were recruited prospectively to provide a single blood sample four weeks after primary immunisation, which was administered by the GP surgery. Vaccination history was obtained at blood sampling. MenC serum bactericidal antibody (SBA) and IgG antibodies against Haemophilus influenzae b (Hib), pertussis toxin (PT), diphtheria toxoid (DT), tetanus toxoid (TT) and thirteen pneumococcal serotypes were analysed according to MCC vaccines received. MenC SBA responses differed significantly (P |
| Databáze: | OpenAIRE |
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