High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer

Autor: Veli-Matti Kosma, Maarit Anttila, Kirsi Hämäläinen, Leea Keski-Nisula, Minna Sopo, Hanna Sallinen, Annukka M. Kivelä, Seppo Ylä-Herttuala
Rok vydání: 2020
Předmět:
Oncology
Colorectal cancer
Angiogenesis
Cancer Treatment
Kaplan-Meier Estimate
Metastasis
Basic Cancer Research
Breast Tumors
Medicine and Health Sciences
Neoplasm Metastasis
Aged
80 and over
Ovarian Neoplasms
Multidisciplinary
Liver Diseases
Receptor
TIE-1
Middle Aged
Prognosis
Receptor
TIE-2
Progression-Free Survival
Ovarian Cancer
Gene Expression Regulation
Neoplastic
Serous fluid
Medicine
Female
Research Article
Adult
medicine.medical_specialty
Science
Gastroenterology and Hepatology
Angiopoietin-2
Malignant Tumors
Breast cancer
Internal medicine
Breast Cancer
Gastrointestinal Tumors
medicine
Humans
Survival analysis
Aged
Colorectal Cancer
business.industry
Carcinoma
Cancers and Neoplasms
Cancer
Hepatocellular Carcinoma
medicine.disease
Cystadenocarcinoma
Serous
Gastric Cancer
Angiogenesis Inducing Agents
Neoplasm Grading
Ovarian cancer
business
Gynecological Tumors
Zdroj: PLoS ONE, Vol 15, Iss 11, p e0241484 (2020)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0241484
Popis: Background Antiangiogenic therapy, although part of standard treatment in ovarian cancer, has variable efficacy. Furthermore, little is known about the prognostic biomarkers and factors influencing angiogenesis in cancer tissue. We evaluated the expression of angiopoietin-2 and two endothelial tyrosine kinase receptors, Tie-1 and Tie-2, and assessed their value in the prediction of survival in patients with malignant epithelial ovarian cancer. We also compared the expression of these factors between primary high grade serous tumors and their distant metastasis. Materials and methods We evaluated 86 women with primary epithelial ovarian cancer. Matched distal omental metastasis were investigated in 18.6% cases (N = 16). The expression levels of angiogenic factors were evaluated by immunohistochemistry in 306 specimens and by qRT-PCR in 111 samples. Results A high epithelial expression level of Tie-2 is a significant prognostic factor in primary high grade serous ovarian cancer. It predicted significantly shorter overall survival both in univariate (p Conclusions The angiogenic factor, angiopoietin-2, and its receptor Tie-2 seem to be significant prognostic factors in primary epithelial ovarian cancer. Their expression levels are also increased in metastatic lesions in comparison with primary tumors.
Databáze: OpenAIRE
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