Glutamine-enriched total parenteral nutrition maintains intestinal interleukin-4 and mucosal immunoglobulin A levels
| Autor: | M. Keith Hanna, Yong Wu, Ben L. Zarzaur, Kazuhiko Fukatsu, Roger Wang, Cheryl D. Johnson, Kenneth A. Kudsk |
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| Rok vydání: | 2000 |
| Předmět: |
Immunoglobulin A
Male medicine.medical_specialty 030309 nutrition & dietetics Glutamine Respiratory System Medicine (miscellaneous) Biology 03 medical and health sciences Mice Random Allocation 0302 clinical medicine Internal medicine medicine Animals Respiratory system Intestinal Mucosa Interleukin 4 0303 health sciences Mice Inbred ICR Nutrition and Dietetics Interleukin Interleukin-10 Interleukin 10 medicine.anatomical_structure Parenteral nutrition Endocrinology biology.protein 030211 gastroenterology & hepatology Parenteral Nutrition Total Interleukin-4 Respiratory tract |
| Zdroj: | JPEN. Journal of parenteral and enteral nutrition. 24(5) |
| ISSN: | 0148-6071 |
| Popis: | Total parenteral nutrition (TPN) prevents progressive malnutrition but fails to maintain intestinal gut-associated lymphoid tissue (GALT) or established respiratory antiviral or antibacterial mucosal immunity. Our previous work demonstrated that decreases in intestinal immunoglobulin A (IgA) were associated with decreases in Th2-type IgA-stimulating cytokines, interleukin (IL)-4 and IL-10. Because glutamine supplementation of TPN partially preserves respiratory defenses and normalizes GALT, we investigated the ability of parenteral glutamine to normalize respiratory and intestinal IgA levels and measured Th2 cytokines in intestinal homogenates.Animals were cannulated and randomly assigned to receive chow (n = 17), TPN (n = 18), or an isonitrogenous, isocaloric TPN solution formulated by removing the appropriate amount of amino acids and replacing them with 2% glutamine (n = 18) for 5 days. Respiratory tract and intestinal washings were obtained for IgA and the intestine homogenized and analyzed for IL-4 and IL-10.TPN decreased intestinal and respiratory IgA in association with decreases in intestinal IL-4 and IL-10 compared with chow-fed animals. Glutamine significantly improved respiratory and intestinal IgA levels, significantly improved IL-4 compared with TPN animals, and maintained IL-10 levels midway between chow-fed and TPN animals.Glutamine-enriched TPN preserved both extraintestinal and intestinal IgA levels and had a normalizing effect on Th2-type IgA-stimulating cytokines. |
| Databáze: | OpenAIRE |
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