Peripheral Nerve Pathology in Two Rottweilers with Neuronal Vacuolation and Spinocerebellar Degeneration
| Autor: | Cl Tartarelli, Carlo Cantile, Andrew P. Mizisin, M Baroni, Claudia Salvadori |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty 040301 veterinary sciences Central nervous system Tetraparesis Degeneration (medical) Muscular Atrophy Spinal 0403 veterinary science 03 medical and health sciences Dogs medicine Recurrent laryngeal nerve Animals Dog Diseases Spinocerebellar Degenerations Neurons General Veterinary business.industry Laryngeal Nerves 04 agricultural and veterinary sciences Anatomy medicine.disease Peripheral 030104 developmental biology medicine.anatomical_structure nervous system Laryngeal paralysis Laryngeal Muscle Female Laryngeal Muscles business Rottweiler |
| Zdroj: | Veterinary Pathology. 42:852-855 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1354/vp.42-6-852 |
| Popis: | Neuronal vacuolation and spinocerebellar degeneration in young Rottweiler dogs is a neurodegenerative condition characterized by neuronal vacuolation of several nuclei in the central nervous system and degeneration of the spinal cord white matter. Here, we describe the morphologic and ultrastructural findings in laryngeal muscles and peripheral nerves of a 16-week-old female and a 32-week-old female Rottweiler dog affected by progressive ataxia and tetraparesis associated with laryngeal paralysis. Lesions were characterized by neurogenic muscle atrophy of the intrinsic laryngeal muscles, and a loss of large myelinated fibers in the recurrent laryngeal nerve, accompanied by demyelinating/remyelinating features affecting the small myelinated fibers. No significant changes were detected in the cranial laryngeal, vagus, phrenic, ulnar, or peroneal nerves. These findings were indicative of a selective distal neuropathy of the recurrent laryngeal nerve with early severe axonal degeneration, mainly of the large myelinated fibers. |
| Databáze: | OpenAIRE |
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