Changes in cognitive functions of patients with dementia of the Alzheimer type following long-term administration of donepezil hydrochloride: Relating to changes attributable to differences in apolipoprotein E phenotype
| Autor: | Minoru Sakai, Hiroko Fujii, Kiyoshi Kanaya, Toshihiko Iwamoto, Shine Abe |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Apolipoprotein E medicine.medical_specialty Longitudinal study Neuropsychological Tests Apolipoproteins E Cognition Piperidines Alzheimer Disease Donepezil Hydrochloride Internal medicine mental disorders Brief Psychiatric Rating Scale Humans Medicine Dementia Donepezil Longitudinal Studies Risk factor Psychiatry Nootropic Agents Aged Retrospective Studies Aged 80 and over business.industry Prognosis medicine.disease Cross-Sectional Studies Phenotype Treatment Outcome Indans Disease Progression Alzheimer's disease business medicine.drug |
| Zdroj: | Geriatrics & Gerontology International. 10:25-31 |
| ISSN: | 1447-0594 1444-1586 |
| DOI: | 10.1111/j.1447-0594.2009.00551.x |
| Popis: | Aim: We conducted a study of changes in cognitive functions by long-term monitoring of dementia of Alzheimer type (DAT) patients to investigate the relationship between the progression of DAT symptoms and the presence of apolipoprotein (ApoE)4. Methods: The subjects consisted of 40 DAT patients who had been treated with donepezil for 3 years or more. The Mini-Mental State Examination (MMSE) and Alzheimer's Disease Assessment Scale – Cognitive Subscale Japanese version (ADAS-Jcog), were conducted annually. The patients were categorized into ApoE4+ and ApoE4- groups. Changes in initial cognitive function assessment score (0 years) were then studied longitudinally at each stage of the observation period (1, 2, 3 years) (Wilcoxon's signed-rank test). Moreover, the scores at each time period were compared cross-sectionally between the two groups (Mann–Whitney U-test). Results: Significant decreases in MMSE scores were observed at the three time periods in both groups (P |
| Databáze: | OpenAIRE |
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