OSMOLALITY OF BRAIN TISSUE AND ITS RELATION TO BRAIN BULK
| Autor: | R. V. Coxon, W. Eugene Stern |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Vasopressin
medicine.medical_specialty Osmosis Vasopressins Potassium Sodium Guinea Pigs Hypertonic Solutions chemistry.chemical_element Sodium Chloride Blood–brain barrier Osmolar Concentration Renal Dialysis Physiology (medical) Internal medicine Blood plasma medicine Urea Infusions Parenteral Pharmacology Research Brain Water-Electrolyte Balance Body Fluids Arginine Vasopressin medicine.anatomical_structure Endocrinology Glucose chemistry Blood-Brain Barrier Anesthesia Tonicity Dialysis Peritoneal Dialysis Blood Chemical Analysis |
| Zdroj: | The American journal of physiology. 206 |
| ISSN: | 0002-9513 |
| Popis: | Changes in the osmolality of the blood plasma of guinea pigs were induced by peroral hydration, coupled with injections of Pitressin, by peritoneal dialysis, and by hypertonic intravenous infusions. Using freezing-point determinations on homogenates the effects of these changes upon the osmolality of the tissue fluids of the brain were investigated. The water content of the brain and its sodium and potassium content were also measured. It was found that a rise or fall in plasma tonicity exceeding about 45 mosmoles/kg water was accompanied by a change of osmolality of the tissue fluids of the brain in the same direction and by a corresponding loss or gain of water. The water movements were sufficient to produce variations in the bulk of the brain which might critically affect intracranial volume-pressure relationships. In untreated animals the osmolality of the brain fluids appeared to be somewhat greater than that of plasma. |
| Databáze: | OpenAIRE |
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