Lymphomas with pseudo–double-hit BCL6-MYC translocations due to t(3;8)(q27;q24) are associated with a germinal center immunophenotype, extranodal involvement, and frequent BCL2 translocations
| Autor: | Jennifer N. Sanmann, Kathleen Kaiser-Rogers, Jayadev Manikkam Umakanthan, R. Gregory Bociek, Steven M Johnson, Yuri Fedoriw, Nathan D. Montgomery, Ji Yuan |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Lymphoma B-Cell Translocation Genetic Immunophenotyping Pathology and Forensic Medicine Proto-Oncogene Proteins c-myc 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases medicine Humans Clinical significance Extranodal Involvement In Situ Hybridization Fluorescence Aged Gene Rearrangement medicine.diagnostic_test business.industry Germinal center Karyotype Gene rearrangement Middle Aged Germinal Center BCL6 Phenotype Proto-Oncogene Proteins c-bcl-2 030220 oncology & carcinogenesis Proto-Oncogene Proteins c-bcl-6 Cancer research Female business 030215 immunology Fluorescence in situ hybridization |
| Zdroj: | Human Pathology. 80:192-200 |
| ISSN: | 0046-8177 |
| Popis: | High-grade B-cell lymphomas with MYC, BCL2, and/or BCL6 rearrangements, "double-hit" or "triple-hit" lymphomas (DTHL), are aggressive neoplasms associated with a poor prognosis. A t(3;8)(q27;q24) rarely occurs in B-cell lymphomas that results in a unique "pseudo-double-hit" BCL6-MYC fusion, indistinguishable by interphase fluorescence in situ hybridization (FISH) from more conventional DTHL with independent MYC and BCL6 translocations. Reports of t(3;8)(q27;q24) lymphomas are sparse, and to better characterize their pathologic, cytogenetic, and clinical features, 6 new cases from 2 institutions and 19 previously published cases were reviewed. All new cases displayed aggressive morphologic features, and most previously published cases were classified as aggressive lymphomas. Collectively, all t(3;8)(q27;q24) cases had a germinal center (GC) phenotype, and most had complex karyotypes (22/24, 92%), including frequent concomitant BCL2 rearrangements (17/24, 71%). When compared to two large published DTHL cohorts, t(3;8)(q27;q24) lymphomas less often expressed BCL2 (P < .01), had a greater likelihood of extranodal involvement (P < .01), and more frequently appeared triple-hit by FISH analysis (P < .01). Despite presenting with aggressive clinicopathologic features, 100% (6/6) of t(3;8;)(q27;q24) patients achieved complete remission after intensive induction regimens, and 2- and 3-year overall survival rates were 63% (10/16) and 57% (8/14), respectively. These findings suggest that lymphomas with t(3;8)(q27;q24) may represent a subset of GC B-cell lymphomas distinct from conventional DTHL. Our results further highlight the value of routine karyotype assessment in aggressive B-cell lymphomas, and the importance of recognizing the t(3;8)(q27;q24) so that its clinical significance can be more fully explored. |
| Databáze: | OpenAIRE |
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