Biomarkers for recurrent pressure injury risk in persons with spinal cord injury
| Autor: | Nannette Alvarado, Katie Schwartz, Kath M. Bogie, David P. Lemmer, Jennifer K Zindle, Mary Ann Richmond, M Kristi Henzel, Jacinta M Seton |
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| Rok vydání: | 2019 |
| Předmět: |
Vascular Endothelial Growth Factor A
Fatty Acid-Binding Proteins Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Recurrence Risk Factors medicine Humans Spinal cord injury Spinal Cord Injuries Research Articles 030304 developmental biology 0303 health sciences Interleukin-13 Pressure injury business.industry medicine.disease Adipose Tissue Spinal Cord Anesthesia Circulatory system Neurology (clinical) business Fatty Acid Binding Protein 3 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | J Spinal Cord Med |
| ISSN: | 2045-7723 |
| Popis: | Objective: To investigate potential linkages between pressure injury (PrI) recurrence following spinal cord injury (SCI) and muscle-based and circulatory biomarkers, specifically fatty metabolites and inflammatory cytokines. Design: Observational study. Setting: Tertiary Care Center. Participants: 30 individuals with complete or incomplete SCI. Study participants either had never developed a PrI (Group I) or had a history of recurrent PrI (Group II). Interventions: Not applicable. Outcome Measures: Gluteal muscle histology, immunohistochemistry, muscle-based and circulatory fatty metabolites and inflammatory cytokines. Results: Gluteal intramuscular adipose tissue (IMAT) was greater than 15% in most Group II (83%) individuals. Muscle tissue histology confirmed intramuscular structural differences. Fatty acid binding protein 4 (FABP4) and fatty acid binding protein 3 (FABP3) were reliably detected in muscle and blood and significantly correlated with IMAT (P |
| Databáze: | OpenAIRE |
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