Intraoperative radiation therapy combined with limited lymph node resection in gastric cancer: An alternative to extended dissection?
| Autor: | François-Noël Gilly, L. Ayzac, Pascale Romestaing, Irénée Sentenac, Braillon G, Yves Francois, Francois-Pierre Rocher, J. Vignal, Jean-Pierre Gerard, Régis Coquard |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty medicine.medical_treatment Adenocarcinoma Intraoperative Period Recurrence Stomach Neoplasms medicine Humans Radiology Nuclear Medicine and imaging Stage (cooking) Intraoperative radiation therapy Lymph node Aged Neoplasm Staging Aged 80 and over Analysis of Variance Radiation business.industry Cancer Middle Aged Prognosis medicine.disease Combined Modality Therapy Surgery Radiation therapy Dissection medicine.anatomical_structure Oncology Lymph Node Excision Female Gastrectomy business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 39:1093-1098 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/s0360-3016(97)00386-6 |
| Popis: | Purpose: To describe the results of a series of 63 Western patients presenting with gastric adenocarcinoma and treated with surgery and intraoperative radiation therapy (IORT) over a 8-year period and to discuss the role of IORT when combined with limited lymph node dissection. Methods and Materials: From 1986 to 1993, 63 patients with gastric adenocarcinoma have been operated in the department of radiation oncology of the Hospices Civils de Lyon. The stage was: I in 17, II in 11, IIIA in 9, IIIB in 20, and IV in 6. The lymph node dissection was considered to be limited in 56 patients and extended in 7. The IORT dose ranged from 12 to 23 Gy (median: 15). Thirty patients also underwent a postoperative external beam irradiation with a standard dose of 44-46 Gy. Results: The postoperative mortality rate was 4.8%. The 5-year overall survival in the entire series was 47% and was 82, 55, 78, 20, and 0% in Stages I, II, IIIA, IIIB, and IV, respectively. Loco-regional relapse occurred in 15 of 63 patients and metastases in 15 of 63. Conclusion: In Western patients treated by gastrectomy for adenocarcinoma of the stomach, IORT combined with limited lymph node dissection may provide overall survival similar to that observed after gastrectomy with extended lymph node dissection but with less postoperative mortality. |
| Databáze: | OpenAIRE |
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