Route to Air and Moisture Stable β-Difluoroboryl Acrylamides

Autor:	Christopher D. Sibley, Carla Slebodnick, Eric J. Medici, Laura G. Wonilowicz, Webster L. Santos, Russell G. Fritzemeier, Connor Szwetkowski
Rok vydání:	2019
Předmět:	chemistry.chemical_compound chemistry Moisture 010405 organic chemistry Organotrifluoroborate Organic Chemistry Organic chemistry Physical and Theoretical Chemistry 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences
Zdroj:	Organic Letters. 21:8053-8057
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.9b03031
Popis:	A method for the preparation of air stable difluoroboryl acrylamides is reported. In contrast to the ubiquitous organotrifluoroborate salts, difluoroboryl acrylamides are relatively nonpolar and are readily purified by silica chromatography. Difluoroboryl acrylamides serve as efficient substrates in cross-coupling reactions to afford the corresponding trisubstituted acrylamides in good to excellent yields. The utility of the difluoroboryl group in various chemical transformations is presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb61712de681bf9103310c7bc9a0829b https://doi.org/10.1021/acs.orglett.9b03031 Zobrazit plný text záznamu