Drug assessment by a Pharmacy and Therapeutics committee: from drug selection criteria to use in clinical practice
| Autor: | Ana Lozano-Blázquez, Fernando Martínez-Martínez, Mónica Carbajales-Álvarez, Patricio Suárez-Gil, Miguel Ángel Calleja-Hernández, Cecilia Calvo-Pita |
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| Přispěvatelé: | [Lozano-Blázquez,A, Carbajales-Álvarez,M] Pharmacy Department, Hospital de Cabueñes, Gijón, Spain. [Calvo-Pita,C] Pharmacy Department, Primary Health Care, Servicio Madrileño de Salud, Dirección Asistencial Oeste, Madrid, Spain. [Suárez-Gil,P] Research Unit Área V, Hospital de Cabueñes, Gijón, Spain. [Martínez-Martínez,F] Universidad de Granada. [Calleja-Hernández,MA] UGC Provincial de Farmacia de Granada, Instituto de Biomedicina de Granada, Hospital Virgen de las Nieves, Granada, Spain. |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
formulary
Drug Drug Utilization medicine.medical_specialty Bevacizumab Therapeutics and Clinical Risk Management media_common.quotation_subject Utilización de Medicamentos Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Thinking::Decision Making [Medical Subject Headings] Health Care::Health Services Administration::Organization and Administration::Pharmacy Administration::Drug Utilization [Medical Subject Headings] Pharmacology Pharmacy and Therapeutics committee Pharmacy and Therapeutics Commitee Toma de Decisiones Formulary Internal medicine medicine Drug utilization Formularios Farmacéuticos como Asunto Pharmacology (medical) Drug selection General Pharmacology Toxicology and Pharmaceutics Pharmacy and Therapeutics Health Care::Health Services Administration::Organization and Administration::Professional Practice::Professional Staff Committees::Pharmacy and Therapeutics Committee [Medical Subject Headings] Original Research media_common Chemical Health and Safety Cetuximab Information Science::Information Science::Communications Media::Publications::Books::Reference Books::Formularies as Topic::Formularies Hospital [Medical Subject Headings] business.industry Head and neck cancer Comité Farmacéutico y Terapéutico decision-making General Medicine Diseases::Neoplasms [Medical Subject Headings] medicine.disease Metastatic breast cancer Neoplasm Information Science::Information Science::Communications Media::Publications::Books::Reference Books::Formularies as Topic [Medical Subject Headings] drug utilization business drug selection Safety Research neoplasm Formularios de Hospitales medicine.drug Decision-making |
| Zdroj: | Digibug. Repositorio Institucional de la Universidad de Granada instname Therapeutics and Clinical Risk Management |
| Popis: | Ana Lozano-Blázquez,1 Cecilia Calvo-Pita,2 Mónica Carbajales-Álvarez,1 Patricio Suárez-Gil,3 Fernando Martínez-Martínez,4 Miguel Ángel Calleja-Hernández51Pharmacy Department, Hospital de Cabueñes, Gijón, Spain; 2Pharmacy Department, Primary Health Care, Servicio Madrileño de Salud, Dirección Asistencial Oeste, Madrid, Spain; 3Research Unit Área V, Hospital de Cabueñes, Gijón, Spain; 4Responsable del Grupo de Investigación en Atención Farmacéutica, Universidad de Granada, 5UGC Provincial de Farmacia de Granada Instituto de Biomedicina de Granada, Hospital Virgen de las Nieves, Granada, SpainBackground: In Spain, hospital medicines are assessed and selected by local Pharmacy and Therapeutics committees (PTCs). Of all the drugs assessed, cancer drugs are particularly important because of their budgetary impact and the sometimes arguable added value with respect to existing alternatives. This study analyzed the PTC drug selection process and the main objective was to evaluate the degree of compliance of prescriptions for oncology drugs with their criteria for use.Methods: This was a retrospective observational study (May 2007 to April 2010) of PTC-assessed drugs. The variables measured to describe the committee's activity were number of drugs assessed per year and number of drugs included in any of these settings: without restrictions, with criteria for use, and not included in formulary. These drugs were also analyzed by therapeutic group. To assess the degree of compliance of prescriptions, a score was calculated to determine whether prescriptions for bevacizumab, cetuximab, trastuzumab, and bortezomib were issued in accordance with PTC drug use criteria.Results: The PTC received requests for inclusion of 40 drugs, of which 32 were included in the hospital formulary (80.0%). Criteria for use were established for 28 (87.5%) of the drugs included. In total, 293 patients were treated with the four cancer drugs in eight different therapeutic indications. The average prescription compliance scores were as follows: bevacizumab, 83% for metastatic colorectal cancer, 100% for metastatic breast cancer, and 82.3% for non-small-cell lung cancer; cetuximab, 62.0% for colorectal cancer and 50% for head and neck cancer; trastuzumab, 95.1% for early breast cancer and 82.4% for metastatic breast cancer; and bortezomib, 63.7% for multiple myeloma.Conclusion: The degree of compliance with criteria for use of cancer drugs was reasonably high. PTC functions need to be changed so that they can carry out more innovative tasks, such as monitoring conditions for drug use.Keywords: decision-making, drug selection, drug utilization, formulary, neoplasm, Pharmacy and Therapeutics committee |
| Databáze: | OpenAIRE |
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