Effect of nephrotoxic treatment with gentamicin on rats chronically exposed to uranium
| Autor: | Isabelle Dublineau, C. Baudelin, Stéphane Grison, Yann Gueguen, Johanna Stefani, Line Grandcolas, Marc Pallardy, Caroline Rouas |
|---|---|
| Přispěvatelé: | Laboratoire de radiotoxicologie et radiobiologie expérimentale (LRTOX), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Radiobiologie et épidémiologie (DRPH/SRBE), Institut de Radioprotection et de SÛreté Nucléaire Direction Générale de l’Armement |
| Rok vydání: | 2010 |
| Předmět: |
inorganic chemicals
Male medicine.medical_specialty [SDV]Life Sciences [q-bio] Diuresis Renal function Toxicology complex mixtures Nephrotoxicity Rats Sprague-Dawley chemistry.chemical_compound Internal medicine medicine Animals Urea Drug Interactions Antibacterial agent Kidney Creatinine Chemistry technology industry and agriculture Proteins medicine.disease Anti-Bacterial Agents Rats Endocrinology medicine.anatomical_structure Toxicity Uranium Kallikreins Kidney Diseases Osteopontin Gentamicins Cell Adhesion Molecules Biomarkers Kidney disease |
| Zdroj: | Toxicology Toxicology, 2011, 279, pp.27--35. ⟨10.1016/j.tox.2010.09.003⟩ |
| ISSN: | 1879-3185 |
| Popis: | Uranium is a radioactive heavy metal with a predominantly chemical toxicity, affecting especially the kidneys and more particularly the proximal tubular structure. Until now, few experimental studies have examined the effect of chronic low-dose exposure to uranium on kidney integrity: these mainly analyse standard markers such as creatinine and urea, and none has studied the effect of additional co-exposure to a nephrotoxic agent on rats chronically exposed to uranium. The aim of the present study is to examine the potential cumulative effect of treating uranium-exposed rats with a nephrotoxic drug. Neither physiological indicators (diuresis and creatinine clearance) nor standard plasma and urine markers (creatinine, urea and total protein) levels were deteriorated when uranium exposure was combined with gentamicin-induced nephrotoxicity. A histological study confirmed the preferential impact of gentamicin on the tubular structure and showed that uranium did not aggravate the histopathological renal lesions. Finally, the use of novel markers of kidney toxicity, such as KIM-1, osteopontin and kallikrein, provides new knowledge about the nephrotoxicity threshold of gentamicin, and allows us to conclude that under our experimental conditions, low dose uranium exposure did not induce signs of nephrotoxicity or enhance renal sensitivity to another nephrotoxicant. © 2010 Elsevier Ireland Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect