Effects of on/off anabolic hPTH and remodelling inhibitors on metaphyseal bone of immobilized rat femurs. Tomographical (pQCT) description and correlation with histomorphometric changes in tibial cancellous bone
| Autor: | G.R. Cointry, Jose R. Zanchetta, Ricardo Francisco Capozza, J.L. Ferretti, Rosa M. Alippi, Webster S. S. Jee, Yan Fei Ma |
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| Rok vydání: | 1995 |
| Předmět: |
Restraint
Physical medicine.medical_specialty Histology Anabolism Physiology Endocrinology Diabetes and Metabolism medicine.medical_treatment Stimulation Drug Administration Schedule Bone resorption Bone remodeling Rats Sprague-Dawley Internal medicine medicine Animals Femur Reduction (orthopedic surgery) Tibia Chemistry Anatomy Peptide Fragments Rats Endocrinology medicine.anatomical_structure Parathyroid Hormone Calcitonin Female Cortical bone Bone Remodeling Tomography X-Ray Computed Cancellous bone |
| Zdroj: | Bone. 17:S321-S327 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/8756-3282(95)00309-2 |
| Popis: | An anabolic effect of hPTH(1-38) (s.c. doses of 200 micrograms/kg/d during 75 days) on trabecular and cortical bone mass is tomographically described in the metaphyseal region of immobilized rat femurs using pQCT technology, in agreement with previous histomorphometrical studies of the proximal tibial metaphyses. Correlations between pQCT and histomorphometrical data showed that this effect derived from a stimulation of endosteal and trabecular bone modeling that induced a transference from trabecular to cortical bone mass. Loss of effects after withdrawal, resulting from a stimulation of bone remodeling, could be total or partially prevented by subsequent s.c. injections of risedronate (5 micrograms/kg/2/wk), 17-B-estradiol (10 micrograms/kg/d) or calcitonin (10 micrograms/kg/d) given during 60 days, in this order of effectiveness. The preventive potency was proportionally related to the reduction induced in histomorphometric indices of bone resorption. |
| Databáze: | OpenAIRE |
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