A One Health investigation of Salmonella enterica serovar Wangata in north-eastern New South Wales, Australia, 2016–2017
| Autor: | Kirsty Hope, Kelly M. J. Simpson, Graeme I. Bell, Siobhan M. Mor, Julie Collins, K. Lawrence, K. Lilly, P. Howard, Vitali Sintchenko, Michael P. Ward, Philippe Porigneaux, Qinning Wang, David N Durrheim, T. Kohlenberg, James E. Flint, Grant A. Hill-Cawthorne, Anke Wiethoelter |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Serotype Salmonella Veterinary medicine Epidemiology medicine.disease_cause Risk Factors Environmental Microbiology Child Aged 80 and over whole genome sequencing biology Transmission (medicine) Middle Aged Infectious Diseases One Health Salmonella enterica outbreaks Animals Domestic Child Preschool Salmonella Infections Female New South Wales Adult salmonellosis Adolescent 030106 microbiology Wildlife Animals Wild Serogroup Young Adult 03 medical and health sciences Disease Transmission Infectious medicine Animals Humans Feces Aged Original Paper Salmonella Infections Animal Infant Newborn Infant Outbreak biology.organism_classification zoonoses 030104 developmental biology Case-Control Studies |
| Zdroj: | Epidemiology and infection Epidemiology and Infection |
| ISSN: | 1469-4409 0950-2688 |
| DOI: | 10.1017/s0950268819000475 |
| Popis: | Salmonella enterica serovar Wangata (S. Wangata) is an important cause of endemic salmonellosis in Australia, with human infections occurring from undefined sources. This investigation sought to examine possible environmental and zoonotic sources for human infections with S. Wangata in north-eastern New South Wales (NSW), Australia. The investigation adopted a One Health approach and was comprised of three complimentary components: a case–control study examining human risk factors; environmental and animal sampling; and genomic analysis of human, animal and environmental isolates. Forty-eight human S. Wangata cases were interviewed during a 6-month period from November 2016 to April 2017, together with 55 Salmonella Typhimurium (S. Typhimurium) controls and 130 neighbourhood controls. Indirect contact with bats/flying foxes (S. Typhimurium controls (adjusted odds ratio (aOR) 2.63, 95% confidence interval (CI) 1.06–6.48)) (neighbourhood controls (aOR 8.33, 95% CI 2.58–26.83)), wild frogs (aOR 3.65, 95% CI 1.32–10.07) and wild birds (aOR 6.93, 95% CI 2.29–21.00) were statistically associated with illness in multivariable analyses. S. Wangata was detected in dog faeces, wildlife scats and a compost specimen collected from the outdoor environments of cases’ residences. In addition, S. Wangata was detected in the faeces of wild birds and sea turtles in the investigation area. Genomic analysis revealed that S. Wangata isolates were relatively clonal. Our findings suggest that S. Wangata is present in the environment and may have a reservoir in wildlife populations in north-eastern NSW. Further investigation is required to better understand the occurrence of Salmonella in wildlife groups and to identify possible transmission pathways for human infections. |
| Databáze: | OpenAIRE |
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