Karyotypic aberrations of chromosomes 16 and 17 are related to survival in patients with breast cancer
| Autor: | David Goudie, S. C. Stocks, C. M. Steel, R. G. Hislop, Norman Pratt, Alastair M. Thompson, Mark Sales, A. Robertson |
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| Rok vydání: | 2002 |
| Předmět: |
Oncology
medicine.medical_specialty Pathology Mammary gland Breast Neoplasms Breast cancer Internal medicine medicine Humans Chromosome Aberrations business.industry Mortality rate Incidence (epidemiology) Cytogenetics Nucleic Acid Hybridization Karyotype medicine.disease Survival Analysis Chromosome 17 (human) medicine.anatomical_structure Karyotyping Surgery Female business Chromosomes Human Pair 16 Comparative genomic hybridization Chromosomes Human Pair 17 Follow-Up Studies |
| Zdroj: | The British journal of surgery. 89(12) |
| ISSN: | 0007-1323 |
| Popis: | Background Breast cancer has a high incidence and associated mortality rate, yet little is known of the sequence of genetic events that underlie the clinical course. Methods The study was a comparative genomic hybridization analysis of 40 primary breast cancers with survival data at a mean of 8·4 years. Results The mean number of aberrations was 9·0, with a mean of 5·5 gains and 3·5 deletions per tumour. The most common aberrations were: gain of 1q (27 of 40), 8q (19 of 40) and 17q (13 of 40), and deletion of 17p (12 of 40) and 8p (11 of 40). These results are consistent with a distinctive pattern of large-scale (karyotypic) genetic change in primary breast cancer. Conclusion The novel findings of this study were that only women who were disease-free had loss of 16q (E-cadherin) in association with a gain of 16p, and 17p13 (p53) loss combined with 17q12 (HER2) amplification was found only in the cancers of women who developed recurrent disease. The karyotypic changes seen in primary breast cancer seem to be associated with outcome and point to the underlying genetic events. |
| Databáze: | OpenAIRE |
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