Cell type specific expression of Follistatin-like 1 (Fstl1) in mouse embryonic lung development
| Autor: | Xue Liu, Yingying Liu, Wen Ning, Zaofeng Yang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Histology Vascular smooth muscle Follistatin-Related Proteins Physiology Cells Myocytes Smooth Muscle Respiratory System Biology Pathogenesis 03 medical and health sciences Mice 0302 clinical medicine medicine Animals Tissue Distribution Lung Mesenchymal stem cell Endothelial Cells Mesenchymal Stem Cells Cell Biology General Medicine respiratory system Embryo Mammalian Embryonic stem cell Epithelium respiratory tract diseases Cell biology 030104 developmental biology medicine.anatomical_structure biology.protein Pericytes 030217 neurology & neurosurgery Blood vessel Follistatin |
| Zdroj: | Journal of molecular histology. 49(4) |
| ISSN: | 1567-2387 |
| Popis: | Follistatin like-1 (Fstl1) is a secreted glycoprotein and can be up-regulated by TGF-β1. To better study the function of Fstl1 in lung development, we examined Fstl1 expression in the developing lung, in a cell type specific manner, using a tamoxifen inducible Fstl1-reporter mouse strain. Our results show that Fstl1 is ubiquitously expressed at saccular stage in the developing lung. At E18.5, Fstl1 expression is robust in most type of mesenchymal cells, including airway smooth muscle cells surrounding airways, vascular smooth muscle cells, endothelial cells, and vascular pericytes from blood vessel, but not PDGFRα+ fibroblasts in the distal alveolar sacs. Meanwhile, relative weak and sporadic signals of Fstl1 expression are observed in epithelium, including a subgroup of club cells in proximal airways and a few type II alveolar epithelial cells in distal airways. Our data help to understand the critical role of Fstl1 in lung development and lung disease pathogenesis. |
| Databáze: | OpenAIRE |
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