LED phototherapy in full-thickness burns induced by CO2 laser in rats skin
| Autor: | Leandro Procópio Alves, Adriana Barrinha Fernandes, Henrique Cunha Carvalho, Miguel Angel Castillo Salgado, Mônica Fernandes Gomes, Milene da Silva Melo, Renato Amaro Zângaro, Carlos José de Lima, Egberto Munin |
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| Přispěvatelé: | Technology and Education CITÉ, Camilo Castelo Branco University (UNICASTELO), Anhembi Morumbi University (UAM), Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Histology CO2 laser Angiogenesis Wound healing Dermatology Led phototherapy Gastroenterology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Immune system Internal medicine Medicine Lymphocytes T CD4+ and T CD8+ Co2 laser business.industry 030206 dentistry LED phototherapy Immunohistochemistry Surgery Full-thickness burns business CD8 |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2018-12-11T17:19:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-09-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Many studies have been conducted on the treatment of burns because they are important in morbidity and mortality. These studies are mainly focused on improving care and quality of life of patients. The aim of this study was evaluate the LED phototherapy effects in rats skin full-thickness burns induced by CO2 laser. The animals were divided in NT group that did not received any treatment and LED group that received LED irradiation at 685 nm, 220 mW, and 4.5 J/cm2 during 40 s by burned area. Biopsies were obtained after 7, 14, and 21 days of treatment and submitted to histological and immunohistochemical analysis. The LED phototherapy shows anti-inflammatory effects, improves angiogenesis, and stimulates the migration and proliferation of fibroblasts. The T CD8+ lymphocytes were more common in burned areas compared to T CD4+ lymphocytes since statistically significant differences were observed in the LED group compared to the NT group after 7 days of treatment. These results showed that LED phototherapy performs positive influence in full-thickness burns repair from the healing process modulated by cellular immune response. The obtained results allowed inferring that burns exhibit a characteristic cell immune response and this cannot be extrapolated to other wounds such as incision and wounds induced by punch, among others. Center for Innovation Technology and Education CITÉ Camilo Castelo Branco University (UNICASTELO) Anhembi Morumbi University (UAM) São José dos Campos Dental School Bioscience Center for Special Health Care (CEBAPE) Institute of Science and Technology Paulista State University (ICT-UNESP) Histology Laboratory São José dos Campos Dental School Institute of Science and Technology Paulista State University (ICT-UNESP) São José dos Campos Dental School Bioscience Center for Special Health Care (CEBAPE) Institute of Science and Technology Paulista State University (ICT-UNESP) Histology Laboratory São José dos Campos Dental School Institute of Science and Technology Paulista State University (ICT-UNESP) FAPESP: 09/53509-2 FAPESP: 11/50468-3 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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