Association of HLA-DRB1 and -DQ Alleles and Haplotypes with Type 1 Diabetes in Jordanians
| Autor: | Yazun Jarrar, Sawsan I. Khdair, Omar Al-Khaldi, Wassan Jarrar, Safa’a Bataineh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male musculoskeletal diseases 0301 basic medicine Adolescent Genotype endocrine system diseases Endocrinology Diabetes and Metabolism Human leukocyte antigen Biology Lower risk HLA-DQ alpha-Chains Young Adult 03 medical and health sciences 0302 clinical medicine Gene Frequency immune system diseases HLA-DQ Antigens Diabetes mellitus medicine HLA-DQ beta-Chains Humans Immunology and Allergy Genetic Predisposition to Disease Allele skin and connective tissue diseases HLA-DRB1 Alleles Genetic Association Studies Type 1 diabetes Jordan Haplotype nutritional and metabolic diseases medicine.disease Diabetes Mellitus Type 1 030104 developmental biology Haplotypes Case-Control Studies Immunology Female HLA-DRB1 Chains 030215 immunology |
| Zdroj: | Endocrine, Metabolic & Immune Disorders - Drug Targets. 20:895-902 |
| ISSN: | 1871-5303 |
| Popis: | Background: The Human Leukocyte Antigen (HLA) class II genes, particularly the HLADR and -DQ loci, have been shown to play a crucial role in Type 1 Diabetes (T1D) development. Objective: This study is the first to examine the contribution of the HLA-DR/DQ alleles and haplotypes to T1D susceptibility in Jordanians. Methods: Polymerase chain reaction sequence-specific primers (PCR-SSP) were used to genotype 41 Jordanian healthy controls and 50 insulin-dependent diabetes mellitus (IDDM) patients. Results: The following alleles were found to be significant high risk alleles in T1D Jordanian patients: DRB1*04 (OR=3.95, p Conclusion: A strong positive association of DRB1*04-DQA1*0301-DQBl*0302 (OR=5.67, p |
| Databáze: | OpenAIRE |
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