Evaluation of Risk and Benefit of Oral Immunomodulation using Heat-killed Enterococcus Faecalis FK-23 Preparation in Healthy Dogs
| Autor: | Yamamoto T, Yamaguchi H, Abe S, Hasegawa T, Shimazu N, Inomata T |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pharmacology
Myeloid medicine.diagnostic_test biology business.industry Lymphocyte Immunology Complete blood count biology.organism_classification Enterococcus faecalis Microbiology medicine.anatomical_structure Immune system Blood chemistry medicine Immunology and Allergy Bone marrow Adverse effect business |
| Zdroj: | International Journal of Immunopathology and Pharmacology. 12:205873929901200 |
| ISSN: | 2058-7384 |
| DOI: | 10.1177/205873929901200205 |
| Popis: | The risk and benefit of oral immunomodulation using heat-killed Enterococcus faecalis FK-23 preparation (FK-23) were evaluated in healthy dogs. Dogs were administered perorally 100 mg/kg of FK23 daily for 3 months. FK-23 did not affect the findings of complete blood count, leukocyte differential count, blood chemistry, serum electrolyte, radiography, or physical conditions of the dogs tested. Increase in myeloid/erythroid ratio and granulocytic lineage was found in bone marrow of the FK-23 treated dogs. Neutrophil function assessed by zymosan-dependent chemiluminescence was activated by treatment of the drug. FK-23 also stimulated in vitro lymphocyte blast transformation of PHA, Con A, and LPS. FK-23 thus appears to be a useful immunomodulating drug to stimulate non-specific host immune responses without adverse side effects. |
| Databáze: | OpenAIRE |
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