Chronic relapsing experimental allergic encephalomyelitis
| Autor: | Henryk M. Wiśniewski, Krister Kristensson |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Nervous system
Pathology medicine.medical_specialty Encephalomyelitis Autoimmune Experimental Encephalomyelitis Guinea Pigs Vascular permeability Horseradish peroxidase Pathology and Forensic Medicine Capillary Permeability Cellular and Molecular Neuroscience Recurrence medicine Animals Horseradish Peroxidase Sensitization biology business.industry Multiple sclerosis medicine.disease Spinal cord medicine.anatomical_structure Spinal Cord Blood-Brain Barrier Permeability (electromagnetism) biology.protein Neurology (clinical) business Evans Blue |
| Zdroj: | Acta Neuropathologica. 39:189-194 |
| ISSN: | 1432-0533 0001-6322 |
| DOI: | 10.1007/bf00691696 |
| Popis: | The vascular permeability in the nervous system to Evans blue-albumin and horseradish peroxidase was studied in chronic relapsing EAE in strain 13 and Hartley guinea pigs. The disease was induced by single sensitization of immature animals and was characterized clinically by remissions and relapses. Recent and old demyelinating plaques in the spinal cord were present. These showed an increased permeability to the protein tracers. The blood-brain barrier in these plaques are therefore disturbed and also in this respect the condition is similar to the multiple sclerosis lesions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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