RETICULAR MACULAR DISEASE IS ASSOCIATED WITH MULTILOBULAR GEOGRAPHIC ATROPHY IN AGE-RELATED MACULAR DEGENERATION
| Autor: | Srilaxmi Bearelly, Anna Blonska, Gregory S. Hageman, Luna Xu, Nicole M. Pumariega, M. A. Sohrab, R. Theodore Smith |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Retinal Drusen Retinal Pigment Epithelium Multimodal Imaging Article Lesion Ophthalmoscopy Macular Degeneration Geographic Atrophy Ophthalmology Retinal Dystrophies medicine Humans Fluorescein Angiography Aged 80 and over Retinal pigment epithelium medicine.diagnostic_test business.industry General Medicine Macular degeneration Fluorescein angiography medicine.disease eye diseases Scanning laser ophthalmoscopy medicine.anatomical_structure Reticular connective tissue Disease Progression Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Retina. 33:1850-1862 |
| ISSN: | 0275-004X |
| DOI: | 10.1097/iae.0b013e31828991b2 |
| Popis: | PURPOSE To investigate the incidence of reticular macular disease (RMD), a subphenotype of age-related macular degeneration, in multilobular geographic atrophy (GA) and its relation to GA progression. METHODS One hundred and fifty-seven eyes of 99 subjects with age-related macular degeneration, primary GA, and good quality autofluorescence, and/or infrared images were classified into unilobular GA (1 lesion) or multilobular GA (≥ 2 distinct and/or coalescent lesions). Thirty-four subjects (50 eyes) had serial imaging. The authors determined the spatiotemporal relationships of RMD to GA and GA progression rates in five macular fields. RESULTS 91.7% eyes (144 of 157) had multilobular GA, 95.8% of which exhibited RMD. In subjects with serial imaging, the mean GA growth rate significantly differed between the unilobular and multilobular groups (0.40 vs. 1.30 mm2/year, P < 0.001). Of the macular fields in these eyes, 77.1% of fields with RMD at baseline showed subsequent GA progression, while 53.4% of fields without RMD showed progression (P < 0.001). Percentage of fields with RMD significantly correlated with GA progression rate (P = 0.01). CONCLUSION Autofluorescence and infrared imaging demonstrates that RMD is nearly always present with multilobular GA in age-related macular degeneration. Furthermore, GA lobules frequently develop in areas of RMD, suggesting progression of a single underlying disease process. |
| Databáze: | OpenAIRE |
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