Evaluating Post-Radiotherapy Laryngeal Function with Laryngeal Videostroboscopy in Early Stage Glottic Cancer
| Autor: | Ariel E. Marciscano, Vivek Charu, Heather M. Starmer, Simon R. Best, Harry Quon, Alexander T. Hillel, Lee M. Akst, Ana P. Kiess |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Cancer Research Glottic function medicine.medical_treatment laryngeal videostroboscopy lcsh:RC254-282 Stroboscope glottic cancer 03 medical and health sciences stroboscopy 0302 clinical medicine dysphonia medicine otorhinolaryngologic diseases Stage (cooking) 030223 otorhinolaryngology radiotherapy Original Research Retrospective review business.industry larynx cancer lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Surgery Radiation therapy Oncology Glottic cancer 030220 oncology & carcinogenesis Post radiotherapy business |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 7 (2017) |
| ISSN: | 2234-943X |
| Popis: | Objective Dysphonia is common among patients with early stage glottic cancer. Laryngeal videostroboscopy (LVS) has not been routinely used to assess post-radiotherapy (RT) voice changes. We hypothesized that LVS would demonstrate improvement in laryngeal function after definitive RT for early-stage glottic cancer. Study design Blinded retrospective review of perceptual voice and stroboscopic parameters for patients with early glottic cancer and controls. Setting High-volume, single-institution academic medical center. Subjects and methods Fifteen patients underwent RT for Tis-T2N0M0 glottic cancer and were evaluated with serial LVS exams pre- and post-RT. Stroboscopic assessment included six parameters: vocal fold (VF) vibration, VF mobility, erythema/edema, supraglottic compression, glottic closure, and secretions. Grade, roughness, breathiness, asthenia, strain (GRBAS) voice perceptual scale was graded in tandem with LVS score. Assessments were grouped by time interval from RT: pre-RT, 0–4, 4–12, and >12 months post-RT. Results 60 LVS exams and corresponding GRBAS assessments were reviewed. There were significant improvements in ipsilateral VF motion (P = 0.03) and vibration (P = 0.001) and significant worsening in contralateral VF motion (P 12 months post-RT. Glottic closure significantly worsened, most prominent >12 months post-RT (P = 0.01). Composite GRBAS scores were significantly improved across all post-RT intervals. Conclusion LVS proved to be a robust tool for assessing pre- and post-RT laryngeal function. We observed post-RT improvement in ipsilateral VF function, a decline in contralateral VF function, and decreased glottic closure. These results demonstrate that LVS can detect meaningful changes in VF and glottic function and support its use for post-RT evaluation of glottic cancer patients. |
| Databáze: | OpenAIRE |
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