Acetylcholine receptor density and acetylcholinesterase activity in skeletal muscle of rats following thermal injury
| Autor: | Richard H. Haschke, John T. Slattery, Edward G. Pavlin, Jonathan R. Zucker, Punit H. Marathe |
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| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Aché Biology chemistry.chemical_compound Internal medicine Muscarinic acetylcholine receptor medicine Animals Receptors Cholinergic Receptor Acetylcholine receptor Thermal injury Muscles Skeletal muscle Rats Inbred Strains musculoskeletal system Acetylcholinesterase language.human_language Diaphragm (structural system) Rats Anesthesiology and Pain Medicine Endocrinology medicine.anatomical_structure chemistry language Female Burns |
| Zdroj: | Anesthesiology. 70(4) |
| ISSN: | 0003-3022 |
| Popis: | Thermal injury causes systemic changes that result in altered sensitivity to many drugs including nondepolarizing muscle relaxants. In an effort to identify the mechanism(s) responsible for the resistance to nondepolarizing muscle relaxants, the density of acetylcholine receptors (AChR) and the activity of acetylcholinesterase (AChE) were determined in rats following a 30% total body surface thermal injury at a time when resistance to atracurium is maximum. AChR density in gastrocnemius and diaphragm was unchanged by thermal injury. Furthermore, the ratio of junctional to extrajunctional AChR in diaphragm was unaltered. Total AChE activity was unchanged in thermally injured rats compared with that in sham-injured animals. Separation of the molecular forms of AChE by sucrose gradient centrifugation also showed no changes in the relative proportions of these species. The mechanism of resistance to nondepolarizing muscle relaxants does not appear to be explained by changes in AChR number or changes in the activity of AChE. |
| Databáze: | OpenAIRE |
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