Light-Mediated Toxicity of Porphyrin-Like Pigments from a Marine Polychaeta
| Autor: | Ana Catarina Santos, A. Jorge Parola, Mariaelena D’Ambrosio, Pedro M. Costa, Alfonso Alejo-Armijo |
|---|---|
| Přispěvatelé: | UCIBIO - Applied Molecular Biosciences Unit, DCV - Departamento de Ciências da Vida, LAQV@REQUIMTE, DQ - Departamento de Química |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
annelida
Aquatic Organisms Porphyrins Oceans and Seas Pharmaceutical Science marine bioproducts porphyrinoids 02 engineering and technology HPLC-DAD Article Eulalia viridis 03 medical and health sciences Pigment chemistry.chemical_compound Drug Discovery Animals Bioassay Photosensitizer SDG 14 - Life Below Water Pharmacology Toxicology and Pharmaceutics (miscellaneous) Heme lcsh:QH301-705.5 030304 developmental biology 0303 health sciences Photosensitizing Agents biology Chemistry Proboscis toxicity Polychaeta Pigments Biological Marine invertebrates photosensitizers 021001 nanoscience & nanotechnology biology.organism_classification Biochemistry lcsh:Biology (General) visual_art Toxicity visual_art.visual_art_medium 0210 nano-technology |
| Zdroj: | Marine Drugs Volume 18 Issue 6 Marine Drugs, Vol 18, Iss 302, p 302 (2020) |
| Popis: | Porphyrins and derivatives form one of the most abundant classes of biochromes. They result from the breakdown of heme and have crucial physiological functions. Bilins are well-known representatives of this group that, besides significant antioxidant and anti-mutagenic properties, are also photosensitizers for photodynamic therapies. Recently, we demonstrated that the Polychaeta Eulalia viridis, common in the Portuguese rocky intertidal, holds a high variety of novel greenish and yellowish porphyrinoid pigments, stored as granules in the chromocytes of several organs. On the follow-up of this study, we chemically characterized pigment extracts from the worm&rsquo s skin and proboscis using HPLC and evaluated their light and dark toxicity in vivo and ex vivo using Daphnia and mussel gill tissue as models, respectively. The findings showed that the skin and proboscis have distinct patterns of hydrophilic or even amphiphilic porphyrinoids, with some substances in common. The combination of the two bioassays demonstrated that the extracts from the skin exert higher dark toxicity, whereas those from the proboscis rapidly exert light toxicity, then becoming exhausted. One particular yellow pigment that is highly abundant in the proboscis shows highly promising properties as a natural photosensitizer, revealing that porphyrinoids from marine invertebrates are important sources of these high-prized bioproducts. |
| Databáze: | OpenAIRE |
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