Painless thyroiditis in a dupilumab-treated patient
| Autor: | Iwayama Hideyuki, Ogawa Tetsuya, Nomura Yuka, Takami Akiyoshi, Daramjav Narantsatsral, Takama Hiroyuki, Morita Hiroyuki, Takagi Junko, Inukai Daisuke, Hirase Syo, Otake Kazuo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Thyroiditis endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Biopsy lcsh:Diseases of the endocrine glands. Clinical endocrinology Hyperthyroidism 0302 clinical medicine Japan Tachycardia Eosinophilia FT3 FT4 Fatigue Thyroid Goitre TSH Atopic dermatitis Dupilumab Anti-thyroid autoantibodies medicine.anatomical_structure Thyroid antibodies 030220 oncology & carcinogenesis Hypertension Thyroid function medicine.symptom Adult medicine.medical_specialty endocrine system Thyroxine (T4) 030209 endocrinology & metabolism Dermatology Thyroglobulin C-reactive protein 03 medical and health sciences Neck pain/discomfort Hypothyroidism Internal Medicine medicine Unusual Effects of Medical Treatment Thyroid scintigraphy June lcsh:RC648-665 business.industry Asian - Japanese medicine.disease body regions Oedema Thyroid ultrasonography Immunoglobulin G4 business |
| Zdroj: | Endocrinology, Diabetes & Metabolism Case Reports Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-4 (2020) |
| ISSN: | 2052-0573 |
| Popis: | Summary Dupilumab an inhibitor of the interleukin (IL)-4R-alpha subunit is used for the treatment of allergic diseases. The patient was a 49-year-old man who received dupilumab for the treatment of severe atopic dermatitis. He presented hyperthyroidism with elevated thyroglobulin and anti-thyroid antibody negativity at 4 months after the initiation of therapy. On scintigraphy, the thyroid radioiodine uptake was low. Ultrasonography showed a diffuse hypoechoic area in the thyroid gland. A pathological study revealed lymphocytic infiltration. The administration of dupilumab was continued because of his atopic dermatitis that showed an excellent response. The patient`s hyperthyroidism changed to hypothyroidism 3 weeks later. Six months later his thyroid function normalized without any treatment. We herein describe the case of a patient with atopic dermatitis who developed painless thyroiditis under treatment with dupilumab. To the best of our knowledge, this is the first report of this event in the literature. Learning points: Dupilumab, a fully human monoclonal antibody that blocks interleukin-4 and interleukin-13, has been shown to be effective in the treatment atopic dermatitis and asthma with eosinophilia. Painless thyroiditis is characterized by transient hyperthyroidism and hypothyroidism and recovery without anti-thyroid treatment. This is the first report of painless thyroiditis as an adverse effect of dupilumab, although conjunctivitis and nasopharyngitis are the main adverse effects of dupilumab. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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