Treatment of ventilation-induced lung injury with exogenous surfactant
| Autor: | Jack J. Haitsma, Diederik Gommers, G. F. Vazquez de Anda, Burkhard Lachmann, Robert A. Lachmann, Serge J. C. Verbrugge |
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| Přispěvatelé: | Anesthesiology, Intensive Care, Intensive care medicine |
| Rok vydání: | 2001 |
| Předmět: |
Artificial ventilation
Male medicine.medical_treatment Drug Evaluation Preclinical Peak inspiratory pressure Lung injury Critical Care and Intensive Care Medicine Positive-Pressure Respiration Rats Sprague-Dawley Random Allocation Pulmonary surfactant medicine Animals Prospective Studies Mechanical ventilation Respiratory Distress Syndrome business.industry Pulmonary Gas Exchange Blood gas tension Respiratory disease Pulmonary Surfactants respiratory system medicine.disease Respiration Artificial respiratory tract diseases Rats Disease Models Animal Anesthesia Respiratory Mechanics Arterial blood Blood Gas Analysis business Lung Volume Measurements Bronchoalveolar Lavage Fluid |
| Zdroj: | Intensive Care Medicine, 27, 559-565. Springer-Verlag Vazquez de Anda, G F, Lachmann, R A, Gommers, D, Verbrugge, S J, Haitsma, J & Lachmann, B 2001, ' Treatment of ventilation-induced lung injury with exogenous surfactant ', Intensive Care Medicine, vol. 27, no. 3, pp. 559-565 . https://doi.org/10.1007/s001340000838 Intensive Care Medicine, 27(3), 559-565. Springer Verlag |
| ISSN: | 1432-1238 0342-4642 |
| DOI: | 10.1007/s001340000838 |
| Popis: | Objective: It has been demonstrated that pulmonary surfactant plays a role in the pathophysiology of ventilation-induced lung injury (VILI). Therefore, we investigated whether exogenous surfactant might restore lung function and lung mechanics in an established model of VILI. Design: Prospective, randomized, animal study. Setting: Experimental laboratory of a university. Subjects: Twenty-four adult male Sprague-Dawley rats. Interventions: First, a group of six animals were killed immediately after induction of anesthesia and used as healthy controls. Then, in 18 rats, VILI was induced by increasing peak inspiratory pressure (PIP) to 45 cmH2O without positive end-expiratory pressure (PEEP) for 20 min. Thereafter, animals were randomly divided into three groups of six animals each: one group was killed immediately after VILI and served as VILI-control. In the other two groups, ventilator settings were changed to a PIP of 30 cmH2O and a PEEP of 10 cmH2O, and a respiratory rate of 40 bpm. One group received a bolus of surfactant and the other group received no treatment. Measurements and results: Blood gas tension and arterial blood pressures were recorded every 30 min for 2 h. After the study period, a pressure-volume curve was recorded. Then, a broncho-alveolar lavage (BAL) was performed to determine protein content, minimal surface tension, and surfactant composition in the BAL fluid. Oxygenation, lung mechanics, surfactant function and composition were significantly improved in the surfactant-treated group compared to the ventilated and non-ventilated control groups. Conclusion: We conclude that exogenous surfactant can be used to treat VILI. |
| Databáze: | OpenAIRE |
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