Effect of bifidobacteria on intestinal injury and flora in a mouse model of ulcerative colitis
| Autor: | Chen Xin, Jin Ruifang, Chen Renping, Wu Wei, Wu Fang, Huang Zhiming, Huang Erjiong, Lin Xiuqing |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Flora Bifidobacteria MIMBb75 Ulcerative colitis Intestinal injury Intestinal flora biology business.industry Low dose Pharmaceutical Science biology.organism_classification medicine.disease Gastroenterology Ulcerative colitis fluids and secretions Clostridium Dextran sulphate Internal medicine Intestinal injury medicine Pharmacology (medical) Hemoglobin Bacteroides business |
| Zdroj: | Tropical Journal of Pharmaceutical Research; Vol 17, No 10 (2018); 2019-2023 |
| ISSN: | 1596-5996 1596-9827 |
| Popis: | Purpose: To investigate the effect of bifidobacteria on intestinal injury and flora in a mouse model of ulcerative colitis (UC).Methods: Mouse model of UC was produced using dextran sulphate sodium (DSS). The mice were divided into seven groups, viz, reference group, MRS-L medium-negative control group, mesalaminepositive control group, high dose bifidobacteria (MIMBb75) group, middle dose MIMBb75 group and low dose MIMBb75 group. Normal mice were used as control. All mice were sacrificed at day 7 of treatment, and colon length, hemoglobin concentration and intestinal flora were determined.Results: Bifidobacteria inhibited UC-induced decreases in mice hemoglobin and UC-induced colon shortening. In addition, it augmented the diversity of intestinal flora and increased the number of bacteroides and Clostridium leptum.Conclusion: Bifidobacteria plays a therapeutic role in UC via regulation of intestinal microflora.Keywords: Bifidobacteria, MIMBb75, Ulcerative colitis, Intestinal injury, Intestinal flora |
| Databáze: | OpenAIRE |
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