Particle replication in nonwetting templates nanoparticles with tumor selective alkyl silyl ether docetaxel prodrug reduces toxicity

Autor:	Jennifer L. Kuijer, J. Christopher Luft, William C. Zamboni, Zishan A. Haroon, Mary E. Napier, Mathew C. Finniss, Allison N. Schorzman, Joseph M. DeSimone, Kevin S. Chu, Charles J. Bowerman
Rok vydání:	2014
Předmět:	Materials science Nanoparticle Bioengineering Docetaxel Pharmacology Article Silyl ether chemistry.chemical_compound Mice Neoplasms medicine Animals Humans General Materials Science Prodrugs Alkyl chemistry.chemical_classification Drug Carriers Mechanical Engineering General Chemistry Prodrug Condensed Matter Physics Small molecule Combinatorial chemistry Xenograft Model Antitumor Assays chemistry Toxicity Wettability Nanoparticles Taxoids Drug carrier medicine.drug
Zdroj:	Nano letters. 14(3)
ISSN:	1530-6992
Popis:	Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle replication in nonwetting templates was used to prepare nanoparticles to passively target solid tumors in an A549 subcutaneous xenograft model. An acid labile prodrug was delivered to minimize systemic free docetaxel concentrations and improve tolerability without compromising efficacy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4b6ab7cd28e61f19828a8453c237e3 https://pubmed.ncbi.nlm.nih.gov/24552251 Zobrazit plný text záznamu