Review of a New Multimodal Antidepressant Vortioxetine
Autor: | M. Oppa, Igor Ondrejka, Gabriela Nosalova, D Cesnekova |
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Rok vydání: | 2016 |
Předmět: |
Vortioxetine
medicine.medical_specialty business.industry vortioxetine General Biochemistry Genetics and Molecular Biology 030227 psychiatry 03 medical and health sciences 0302 clinical medicine sexual dysfunction depression inadequate response Medicine Antidepressant business Psychiatry cognitive function 030217 neurology & neurosurgery General Nursing |
Zdroj: | Acta Medica Martiniana, Vol 16, Iss 2, Pp 44-48 (2016) |
ISSN: | 1335-8421 |
Popis: | Vortioxetine is a novel antidepressant with two mechanisms of action – direct effect on several serotonin receptors and serotonin re-uptake inhibition. It shows antidepressant, anxiolytic and cognitive effects during the treatment of major depressive disorder (MDD). The aim of this article was to summarize the use of vortioxetine in clinical studies and assess the efficacy and tolerability. Most of the studies reported a statistically significant efficacy for vortioxetine versus placebo. In addition, vortioxetine showed efficacy in patients with an inadequate response to selective serotonin re-uptake inhibitors (SSRI) or serotonin-noradrenaline re-uptake inhibitors (SNRI) monotherapy and improved cognitive function in patients with MDD. In these studies, vortioxetine was well tolerated – most common observed adverse effect was nausea – and it was not associated with clinically important changes in laboratory test results or vital signs. Vortioxetine showed a relatively low incidence of sexual dysfunction. |
Databáze: | OpenAIRE |
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