Bacteremia and fungemia occurring during antimicrobial prophylaxis with ofloxacin in cancer patients: risk factors, etiology and outcome
| Autor: | I. Ilavska, M. Studena, E. Kukuckova, Vladimir Krcmery, P. Koren, J. Lacka, L. Helpianska, Stanislav Spanik, E. Oravcova, P. Pichna, J. Trupl, L. Drgona, A. Demitrovicova, V. Rusnakova |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Ofloxacin Slovakia Bacteremia Microbial Sensitivity Tests Neutropenia Opportunistic Infections Disease Outbreaks Risk Factors Internal medicine Neoplasms Medicine Humans Pharmacology (medical) Fungemia Antibacterial agent Retrospective Studies Pharmacology Leukopenia Catheter insertion biology business.industry Incidence bacterial infections and mycoses medicine.disease biology.organism_classification Surgery Catheter Stenotrophomonas maltophilia Infectious Diseases Treatment Outcome Oncology medicine.symptom business |
| Zdroj: | Journal of chemotherapy (Florence, Italy). 8(5) |
| ISSN: | 1120-009X |
| Popis: | The authors analyzed 27 breakthrough bacteremias occurring during ofloxacin prophylaxis in afebrile neutropenia over 7 years in 9989 admissions and 979 bacteremic and fungemic episodes in a National Cancer Center in Bratislava, Slovak Republic. The most frequently isolated organisms in breakthrough bacteremias were gram-positive (71.3%), mainly coagulase-negative staphylococci (41.3%), enterococci (9.2%) and Corynebacteria (9.2%), followed by gram-negative rods-Pseudomonas aeruginosa (13.2%) and Stenotrophomonas maltophilia (9.2%). The outcome of breakthrough bacteremias during ofloxacin prophylaxis was not associated with the underlying disease, neutropenia, catheter insertion or resistance, but only with multiple risk factors. A higher failure rate was observed in those patients having a catheter infected with a resistant organism and during neutropenia. No patients with Hickman catheter were included in the study. Patients with mixed breakthrough bacteremia due to gram-negative and gram-positive organisms had higher failure rates than those with monomicrobial bacteremia. Catheter extraction and rapid institution of intravenous antibiotics in combination should be administered in breakthrough bacteremia. |
| Databáze: | OpenAIRE |
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