Evaluation of current diagnostic methods for COVID-19
| Autor: | Cem Bulent Ustundag, Saadet Alpdağtaş, Elif Ilhan, Mustafa Sengor, Ebru Uysal, Oguzhan Gunduz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Medical technology
lcsh:Biotechnology Biomedical Engineering Biophysics Reviews Bioengineering Disease medicine.disease_cause Virus Biomaterials Antigen lcsh:TP248.13-248.65 Pandemic Medicine Coronavirus biology business.industry RNA virus biology.organism_classification medicine.disease Virology lcsh:R855-855.5 biology.protein Antibody business Pneumonia (non-human) |
| Zdroj: | APL Bioengineering APL Bioengineering, Vol 4, Iss 4, Pp 041506-041506-12 (2020) |
| ISSN: | 2473-2877 |
| DOI: | 10.1063/5.0021554 |
| Popis: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent responsible for the coronavirus disease of 2019 (COVID-19), which triggers lung failure, pneumonia, and multi-organ dysfunction. This enveloped, positive sense and single-stranded RNA virus can be transmitted through aerosol droplets, direct and indirect contacts. Thus, SARS-CoV-2 is highly contagious and has reached a pandemic level in a few months. Since COVID-19 has caused numerous human casualties and severe economic loss posing a global threat, the development of readily available, accurate, fast, and cost-effective diagnostic techniques in hospitals and in any places where humans spread the virus is urgently required. COVID-19 can be diagnosed by clinical findings and several laboratory tests. These tests may include virus isolation, nucleic acid-based molecular assays like real-time polymerase chain reactions, antigen or antibody-based immunological assays such as rapid immunochromatographic tests, enzyme-linked immunosorbent assays, immunofluorescence techniques, and indirect fluorescent antibody techniques, electrochemical sensors, etc. However, current methods should be developed by novel approaches for sensitive, specific, and accurate diagnosis of COVID-19 cases to control and prevent this outbreak. Thus, this review will cover an overview and comparison of multiple reports and commercially available kits that include molecular tests, immunoassays, and sensor-based diagnostic methods for diagnosis of COVID-19. The pros and cons of these methods and future perspectives will be thoroughly evaluated and discussed. |
| Databáze: | OpenAIRE |
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