Emotion processing in schizophrenia: fMRI study of patients treated with risperidone long-acting injections or conventional depot medication
| Autor: | Anthony Evans, Christine Ecker, Simon Surguladze, Anantha P. Anilkumar, Elvina M. Chu, Colm McDonald, Anthony S. David, Mary L. Phillips, Nicolette Marshall, Clive Timehin |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Emotions Audiology Emotional processing Amygdala medicine Humans Pharmacology (medical) Attention Prefrontal cortex Psychiatry Antipsychotic Aged Pharmacology Facial expression Brain Mapping Risperidone medicine.diagnostic_test Brain Middle Aged medicine.disease Magnetic Resonance Imaging Facial Expression Psychiatry and Mental health medicine.anatomical_structure Schizophrenia Delayed-Action Preparations Schizophrenic Psychology Functional magnetic resonance imaging Psychology Photic Stimulation Psychomotor Performance medicine.drug Antipsychotic Agents |
| Zdroj: | Journal of psychopharmacology (Oxford, England). 25(6) |
| ISSN: | 1461-7285 |
| Popis: | We employed two event-related functional magnetic resonance imaging tasks using the pictures of mild and intense facial emotions of fear or happiness. The sample comprised 16 chronic schizophrenia patients treated with risperidone long-acting injections (RLAI), 16 patients treated with conventional antipsychotic depots (CONV) and 16 healthy controls (HC). The HC and RLAI groups demonstrated greater activation in the left amygdala in response to intensively fearful faces, and in right cerebellum to intensively happy faces compared with CONV patients. The CONV group demonstrated under-activation in the right temporal pole in response to intensively happy faces (compared with HC) and over-activation in ventro-medial prefrontal cortex (VMPFC) in response to both intensively happy and fearful expressions, compared with HC and RLAI groups. Our results suggest that networks implicated in the allocation of attentional resources (VMPFC) and emotion processing (amygdala, cerebellum) are differentially affected in patients on CONV versus RLAI. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|