Mechanical stress increases brain amyloid β, tau, and α‐synuclein concentrations in wild‐type mice
| Autor: | Bruno Dubois, Erwan Bigan, Olivier Lafitte, Laurent Schwartz, Mohammad Abolhassani, Jean-Marc Steyaert, Minoo Hamraz, Marcel Levy Nogueira |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Parkinson's disease Amyloid Amyloid β Epidemiology Traumatic brain injury tau Proteins Random Allocation 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Developmental Neuroscience Internal medicine medicine Animals Brain Concussion Mice Inbred BALB C Amyloid beta-Peptides Chemistry Health Policy Neurodegeneration Brain Wild type mice medicine.disease Peptide Fragments Biomechanical Phenomena Disease Models Animal Psychiatry and Mental health 030104 developmental biology Endocrinology Brain concentrations alpha-Synuclein α synuclein Stress Mechanical Neurology (clinical) Geriatrics and Gerontology 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer's & Dementia. 14:444-453 |
| ISSN: | 1552-5279 1552-5260 |
| Popis: | Introduction Exposure to traumatic brain injury is a core risk factor that predisposes an individual to sporadic neurodegenerative diseases. We provide evidence that mechanical stress increases brain levels of hallmark proteins associated with neurodegeneration. Methods Wild-type mice were exposed to multiple regimens of repetitive mild traumatic brain injury, generating a range of combinations of impact energies, frequencies, and durations of exposure. Brain concentrations of amyloid β 1–42 (Aβ 1–42 ), total tau, and α-synuclein were measured by sandwich enzyme-linked immunosorbent assay. Results There was a highly significant main effect of impact energy, frequency, and duration of exposure on Aβ 1–42 , tau, and α-synuclein levels ( P 1–42 and tau ( P Discussion Dose-dependent and cumulative influence of repetitive mild traumatic brain injury–induced mechanical stress may trigger and/or accelerate neurodegeneration by pushing protein concentration over the disease threshold. |
| Databáze: | OpenAIRE |
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