Assessment of endogenous allergenicity of genetically modified plants exemplified by soybean - Where do we stand?
| Autor: | Karin Hoffmann-Sommergruber, Clare Mills, J.-M. Wal, F.J. Moreno, Martinus Løvik, Regina Selb, Antonio Fernandez |
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| Přispěvatelé: | European Food Safety Authority = Autorité européenne de sécurité des aliments, Laboratoire d'Etudes et de Recherches en Immunoanalyses (LERI), Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Médicaments et Technologies pour la Santé (MTS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Paris-Saclay, Instituto de Investigación en Ciencias de la Alimentación (CIAL), Norwegian Institute of Public Health [Oslo] (NIPH), School of Biological Sciences, Manchester Academic Health Sciences Centre, Manchester Institute of Biotechnology, University of Manchester, Department of Pathophysiology and Allergy Research, Medizinische Universität Wien = Medical University of Vienna-Christian Doppler Laboratory for Immunomodulation |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Endogenous allergenicity
[SDV]Life Sciences [q-bio] Population Allergic sensitisation Genetically modified crops Biology Toxicology Risk Assessment 03 medical and health sciences 0404 agricultural biotechnology 0302 clinical medicine Food allergy Genetically modified plants medicine Humans education 2. Zero hunger education.field_of_study Oral food challenge business.industry GMO 04 agricultural and veterinary sciences General Medicine Allergens medicine.disease Plants Genetically Modified 040401 food science Biotechnology Genetically modified organism 030228 respiratory system 13. Climate action Identification (biology) Soybeans Risk assessment business Soybean Food Hypersensitivity Food Science |
| Zdroj: | Food and Chemical Toxicology Food and Chemical Toxicology, Elsevier, 2017, 101, pp.139-148. ⟨10.1016/j.fct.2017.01.014⟩ Digital.CSIC. Repositorio Institucional del CSIC instname Food and Chemical Toxicology, 2017, 101, pp.139-148. ⟨10.1016/j.fct.2017.01.014⟩ |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2017.01.014⟩ |
| Popis: | Review. According to EU regulation, genetically modified (GM) plants considered to be allergenic have to be assessed concerning their endogenous allergens before placement on the EU market, in line with the international standards described in Codex Alimentarius. Under such premises, a quantitative relevant increase in allergens might occur in GM plants as an unintended effect compared with conventionally produced crops, which could pose a risk to consumers. Currently, data showing a connection between dose and allergic sensitisation are scarce since the pathophysiological mechanisms of sensitisation are insufficiently understood. In contrast, data on population dose-distribution relationships acquired by oral food challenge are available showing a connection between quantity of allergenic protein consumed and the population of allergic individuals experiencing reactions. Soybean is currently the only recognised allergenic GM food by law for which EFSA has received applications and was therefore taken as an example for defining an assessment strategy. Identification of potential allergens, methodology for quantification as well as risk assessment considerations, are discussed. A strategy is proposed for the identification, assessment and evaluation of potential hazards/risks concerning endogenous allergenicity in food derived from plants developed by biotechnology. This approach could be expanded to other allergenic foods in the future, whenever required. |
| Databáze: | OpenAIRE |
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