The Prevalence of White-Matter Lesions on Computed Tomography of the Brain in Demented and Nondemented 85-Year-Olds
| Autor: | Ingmar Skoog, Bo Palmertz, Lars-Arne Andreasson |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Physical examination Disease Central nervous system disease 03 medical and health sciences 0302 clinical medicine Degenerative disease 0504 sociology mental disorders Prevalence medicine Humans Dementia Longitudinal Studies Vascular dementia Geriatric Assessment Aged Aged 80 and over Psychiatric Status Rating Scales medicine.diagnostic_test business.industry 05 social sciences Neuropsychology Brain 050401 social sciences methods medicine.disease United States Hyperintensity 030227 psychiatry Surgery Psychiatry and Mental health Female Neurology (clinical) Geriatrics and Gerontology Tomography X-Ray Computed business |
| Zdroj: | Journal of Geriatric Psychiatry and Neurology. 7:169-175 |
| ISSN: | 1552-5708 0891-9887 |
| DOI: | 10.1177/089198879400700308 |
| Popis: | The prevalence of white-matter lesions on computed tomography was studied in a representative sample of 85-year-olds living in Gothenburg, Sweden. The study included a psychiatric examination, interview of a close informant, neuropsychological examination, physical examination, comprehensive laboratory tests, electrocardiogram, chest x-ray, computed tomography scan of the head, and cerebrospinal fluid analysis. The diagnoses of dementia and other mental disorders were made according to DSM-III-R criteria. The prevalence of white-matter lesions in demented subjects was 68.9%, and in nondemented, 33.8%. Their prevalence was not increased in any mental disorder other than dementia. All severities of dementia and the subtypes, Alzheimer's disease, vascular dementia, and other types of dementia, had a significantly higher prevalence of white-matter lesions than did nondemented subjects. The risk for dementia, but not its severity, increased with the severity of these lesions. A stepwise logistic regression analysis showed that both white-matter lesions and infarcts on computed tomography contributed independently to dementia. White-matter changes may be a contributing cause of dementia in the oldest old, or may represent a disease entity of its own. They are important to recognize since they may be potentially preventable, or even treatable. |
| Databáze: | OpenAIRE |
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