Pernicious anemia in Chinese: a study of 181 patients in a Hong Kong hospital
| Autor: | Joycelyn Sim, Herman Sung Yu Liu, J. C. W. Chan, Thomas Kwan Hang Lau, Yiu Wing Luk, Bonnie Chi Sang Kho, Raymond W. Chu, Frankie Pak Tat Choi, Florence Man Fung Cheung, Edmond S. K. Ma |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Intrinsic Factor Male medicine.medical_specialty Anemia Schilling Test Fluoroimmunoassay Chronic gastritis Gastroenterology Risk Assessment Schilling test Asian People Parietal Cells Gastric Risk Factors Internal medicine Anemia Pernicious medicine Humans Serologic Tests Prospective Studies Megaloblastic anemia pernicious anemia Parietal cell Aged Aged 80 and over Intrinsic factor medicine.diagnostic_test business.industry Thyroid disease General Medicine Middle Aged medicine.disease Hospitalization Vitamin B 12 Endocrinology medicine.anatomical_structure Hong Kong Female business |
| Zdroj: | Medicine. 85(3) |
| ISSN: | 0025-7974 |
| Popis: | To study the clinical and hematologic features of pernicious anemia in Chinese, we describe 181 Chinese with megaloblastic anemia and low serum cobalamin, in association with either classic Schilling test results (82 patients) or the presence of serum antibody to intrinsic factor (99 patients), encountered in a regional hospital in Hong Kong from May 1994 to May 2005. The median age was 75 years (range, 32-95 yr) and the male to female ratio was 1:1.5. The chief presenting feature was anemia, and fewer than 10% of patients presented predominantly with neurologic deficit. Gastric biopsies of 109 patients showed glandular atrophy in 73, endocrine cell hyperplasia in 5, polyps in 14, adenocarcinoma in 1, and chronic gastritis in the rest. Gastric adenocarcinoma occurred in 1.7% of patients after a median follow-up of 35 months (range, 0.5-132 mo). Diabetes mellitus occurred in 24% of patients and thyroid disease in 7%. No specific ABO blood group was associated with pernicious anemia. Serum antibody to intrinsic factor (73%) occurred more frequently than serum antibody to gastric parietal cell (65%) (p=0.353). The frequency of serum antibody to gastric parietal cell was higher in male (78%) than in female patients (53%) (p=0.018). Pernicious anemia is a major cause of megaloblastic anemia in Chinese. |
| Databáze: | OpenAIRE |
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