Changes of EEG spectra in rat brains with different patterns of dysplasia in response to pilocarpine-induced seizures
| Autor: | Władysław P. Węglarz, Michal Kielbinski, Zuzanna Setkowicz, Kinga Gzielo, Krzysztof Janeczko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Electroencephalography Muscarinic Agonists Midbrain 03 medical and health sciences Behavioral Neuroscience Epilepsy 0302 clinical medicine Pregnancy Seizures medicine Animals developmental disorders 030212 general & internal medicine Rats Wistar medicine.diagnostic_test business.industry Pilocarpine Brain Cortical dysplasia medicine.disease dysplastic brain Pons Prenatal development gamma irradiation Rats Malformations of Cortical Development neurogenesis Neurology Dysplasia Gamma Rays epilepsy Female Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Popis: | Disorders of neurogenesis at early developmental stages lead to irreversible structural and functional impairments of the brain. As further their consequences, increases in brain excitability and the development of drug-resistant epilepsy can frequently be observed in clinical cases. Mechanisms underlying these phenomena can also be examined on animal models of brain dysplasia. This study was conducted on rats with four degrees of brain dysplasia following exposure to gamma radiation on days 13, 15, 17, or 19 of prenatal development. When reached adulthood, the rats received electroencephalographic (EEG) transmitter implantation. Thereafter, pilocarpine was administered, and significant differences in susceptibility to seizures were detected depending on the degree of brain dysplasia. Before, during, and after the seizures, EEG was recorded in free moving animals. Additionally, the intensity of seizure behavioral symptoms was assessed. Strong and moderate correlations were found between the intensity of seizure behavioral symptoms, the power of particular EEG bands, and volumes of dysplastic brains and their regions. The data drew particular attention to correlations between variations in EEG spectra and changes in the midbrain and pons volumes. The results point to possible significant roles of these regions in the observed changes of susceptibility to seizures. Consequently, the frequently used experimental model was considered here not only as representing cases of cortical dysplasia but also of generalized, diffuse dysplasia of the whole brain. |
| Databáze: | OpenAIRE |
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