Targeting evolution of antibiotic resistance by SOS response inhibition
| Autor: | Irina V. Bakhlanova, Alexander Yakimov, Dmitry M. Baitin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
DNA repair Antibiotic resistance Biophysics Mutagenesis (molecular biology technique) Review Article Computational biology Biology Biochemistry Computer Science Applications 03 medical and health sciences 0302 clinical medicine Structural Biology 030220 oncology & carcinogenesis Antibiotic therapy Horizontal gene transfer Genetics Bacterial SOS response RecA inhibition SOS response Homologous recombination TP248.13-248.65 030304 developmental biology Biotechnology |
| Zdroj: | Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 777-783 (2021) Computational and Structural Biotechnology Journal |
| ISSN: | 2001-0370 |
| Popis: | Antibiotic resistance is acquired in response to antibiotic therapy by activating SOS-depended mutagenesis and horizontal gene transfer pathways. Compounds able to inhibit SOS response are extremely important to develop new combinatorial strategies aimed to block mutagenesis. The regulators of homologous recombination involved in the processes of DNA repair should be considered as potential targets for blocking. This review highlights the current knowledge of the protein targets for the evolution of antibiotic resistance and the inhibitory effects of some new compounds on this pathway. |
| Databáze: | OpenAIRE |
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